ID H0XEV8_OTOGA Unreviewed; 547 AA.
AC H0XEV8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Adhesion G protein-coupled receptor G3 {ECO:0000313|Ensembl:ENSOGAP00000014506.2};
GN Name=ADGRG3 {ECO:0000313|Ensembl:ENSOGAP00000014506.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014506.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014506.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03092924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03092927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XEV8; -.
DR STRING; 30611.ENSOGAP00000014506; -.
DR Ensembl; ENSOGAT00000016205.2; ENSOGAP00000014506.2; ENSOGAG00000016197.2.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000154285; -.
DR HOGENOM; CLU_002753_3_9_1; -.
DR InParanoid; H0XEV8; -.
DR OMA; TLFKGPQ; -.
DR TreeFam; TF321769; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR003910; GPR1/GPR3/GPR5.
DR PANTHER; PTHR12011:SF285; ADHESION G PROTEIN-COUPLED RECEPTOR G3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01422; GPR56ORPHANR.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..547
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003544874"
FT TRANSMEM 274..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 265..522
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 527..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 60309 MW; 6B9ECE8649724553 CRC64;
MAHVRSLLLL LALLDEKTTE APRNPCLRPI YETQYDFRNL EDKAECFTRC GQLGSEPCSV
GNLQRYWLNY EVHLVEKSWA ERVNMTFVKA LVQNFSTATP EDLFFSLKPS QIPRQVIKGE
DKPPDRVRLP KSLFGSLPGN RTLVRLAITI LNIGPGSLFK GPRLSLEDGG SVLNNRLVGL
SVGQTLVTGL AEPLEITFSH QRQPPNMTVT CVFWDVTKGR AWRTLSGLGP SSSLPSPALS
LWPFLPLPSS PPLHVALASS TVLALTRISQ AGCGVSMIFL AFTIALYVVL RLSRQRFKSE
DAPKIHVALS VSLFLLNLAF LVNVGSGSKG SDVACWVRGA ILHYFLLCVF TWMGLEAFHL
YLLVIRVFNT YYGHYFLKLS LVGWGLPTLM VIGTGSANSY GLYTIHDQEN RTSLELCWFR
SGTAVHALYA TVHGYFIVTF LFSAVVLALV AWKIFTLSSA TAGKEKGQHR KGLLTVLGLS
SLVGVTWGLA VLTPLGLSTT YIFTFFNSLQ GVFIFCWFTI LYLPSQSATS SSSGTARLDQ
AHSTSHE
//
