ID H0XF73_OTOGA Unreviewed; 567 AA.
AC H0XF73;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Regulator of G protein signaling 14 {ECO:0000313|Ensembl:ENSOGAP00000014649.2};
GN Name=RGS14 {ECO:0000313|Ensembl:ENSOGAP00000014649.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014649.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014649.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}.
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DR EMBL; AAQR03181158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03181159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03181160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03181161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XF73; -.
DR STRING; 30611.ENSOGAP00000014649; -.
DR Ensembl; ENSOGAT00000016368.2; ENSOGAP00000014649.2; ENSOGAG00000016361.2.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000161364; -.
DR HOGENOM; CLU_024780_1_1_1; -.
DR InParanoid; H0XF73; -.
DR OMA; SQGCLPR; -.
DR TreeFam; TF328814; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0005819; C:spindle; IEA:Ensembl.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:InterPro.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR GO; GO:0032794; F:GTPase activating protein binding; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR GO; GO:0007612; P:learning; IEA:Ensembl.
DR GO; GO:0007616; P:long-term memory; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:Ensembl.
DR GO; GO:0010070; P:zygote asymmetric cell division; IEA:Ensembl.
DR CDD; cd17137; RBD1_RGS14; 1.
DR CDD; cd17139; RBD2_RGS14; 1.
DR CDD; cd08743; RGS_RGS14; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR046992; RBD1_RGS14.
DR InterPro; IPR046993; RBD2_RGS14.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037881; RGS14_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF2; REGULATOR OF G-PROTEIN SIGNALING 14; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 67..184
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 303..373
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 375..445
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 24..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 61691 MW; F6BC4A1CEB1C6377 CRC64;
MPGKPKHLGV PNGRMVLAVS DGELNNTTGA QGQGQGRGSS LSIHSLPSGP SSPFPTEEQP
VASWALSFER LLQDPLGLAY FTEFLKKEFS AENVTFWKAC ERFQQIPASD TQQLAQEARN
IYQEFLSSQA LSPVNIDRQA WLGEEVLAEP RPDMFRAQQL QIFNLMKFDS YARFVKSPLY
RECLLAEAEG RPLRKPSSSH LGSPDSTRKK PKLKPGKSLP LGVEELGQLP PAEGPAGRQL
RKSFRRELAG GATNSALRRE SQGSLNSSAS LDLGFLAFVS NKSESHRKSL GSTEGESESR
PGKYCCVYLP DGTASLALAR PGFTIRDMLA GICEKRGLSL PDIKVYLVGN EQALVLDQEC
TVLADQEVRL ENRITFELEL AALERVVRIS AKPTKRLQDA LQPILEKHGL SPQQVALHRP
GEKQPLDLKK LVSSVAAQRL VLNTCPGREC WPSCGSDPTF LQGCLPRTQD KATHPPSVPP
NSVVKLSGSA TGKRQTCDIE GLVELLNRVQ SSGAHDQRGL LRKEDLVLPE FLQLPAQGPS
SQEAPPQTES AAQPIGGALN STAHPAL
//
