ID H0XFC1_OTOGA Unreviewed; 250 AA.
AC H0XFC1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Metaxin 2 {ECO:0000313|Ensembl:ENSOGAP00000014700.2};
GN Name=MTX2 {ECO:0000313|Ensembl:ENSOGAP00000014700.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014700.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014700.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
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DR EMBL; AAQR03082864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03082865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03082866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03082867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03082868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XFC1; -.
DR STRING; 30611.ENSOGAP00000014700; -.
DR Ensembl; ENSOGAT00000016429.2; ENSOGAP00000014700.2; ENSOGAG00000016422.2.
DR eggNOG; KOG3027; Eukaryota.
DR GeneTree; ENSGT00950000182919; -.
DR HOGENOM; CLU_044137_6_0_1; -.
DR InParanoid; H0XFC1; -.
DR OMA; YFQTRCL; -.
DR TreeFam; TF313422; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0001401; C:SAM complex; IEA:Ensembl.
DR GO; GO:0006839; P:mitochondrial transport; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03211; GST_C_Metaxin2; 1.
DR CDD; cd03079; GST_N_Metaxin2; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF38; METAXIN-2; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 28..148
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 174..236
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
SQ SEQUENCE 250 AA; 28446 MW; 234D516CFA663446 CRC64;
ATEPWPENAT LYQQLKGEQI LLSDNAASLA VQAFLQMCNL PIKVVCRANA EYMSPSGKLP
FIHVGNQVVS ELGPIVQFVK AKGHSLSDGL DEVQKAEMKA YMELVNNMLL TAELYLQWCD
EATVGEITHA RYGSPYPWPL NHILAYQKQW EIKRKMKAIG WGNKTLDQVL EDVDQCCQAL
SQRLGTQPYF FNKQPTELDA LVFGHLYTIL TTQLTNDELS EKVKNYSNLL AFCRRIEQHY
FEDRGKGRLS
//
