ID H0XFF1_OTOGA Unreviewed; 1210 AA.
AC H0XFF1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 08-NOV-2023, entry version 52.
DE SubName: Full=MAM domain containing 4 {ECO:0000313|Ensembl:ENSOGAP00000014735.2};
GN Name=MAMDC4 {ECO:0000313|Ensembl:ENSOGAP00000014735.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000014735.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000014735.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; AAQR03116380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XFF1; -.
DR STRING; 30611.ENSOGAP00000014735; -.
DR Ensembl; ENSOGAT00000016469.2; ENSOGAP00000014735.2; ENSOGAG00000016460.2.
DR eggNOG; KOG1095; Eukaryota.
DR GeneTree; ENSGT00940000162046; -.
DR HOGENOM; CLU_008233_0_0_1; -.
DR InParanoid; H0XFF1; -.
DR OMA; CWVRERV; -.
DR TreeFam; TF330345; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR CDD; cd06263; MAM; 4.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282:SF129; APICAL ENDOSOMAL GLYCOPROTEIN; 1.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00629; MAM; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00137; MAM; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS50060; MAM_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1210
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003545937"
FT TRANSMEM 1149..1171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..222
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 269..425
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 491..637
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 647..803
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 805..963
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 965..1132
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DISULFID 229..241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 236..254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 475..490
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1210 AA; 132244 MW; 0C25E4D4EAE0D9CF CRC64;
MRLLGYLLPS LLLLIAGALG WAWVPSHCRP PSEAVCNFLC DCSSCSDEEQ CGHHGASPAL
GTPFSCDFEQ DPCGWQDIST SGYSWIRDRA GATLEGPGPH SDHTLGTDLG WHMAVGTHRG
KEVSTAVLRS PTLREAAPTC ELRLWYHVAS GDVAELSLQL THNTETLTLW WSSGPWGPGW
QELAVTIGRI RGDFRVTFSA TRNATHRGTV GLDDIEFWGC GLPTPQASCP PGHHHCQNKA
CIEPHQLCDG EDSCGDLSDE DPLTCGHHMV TNFETGLGPW NHLEGWVRNH SNASPEHPAW
PHRDHSQNSV RGSFLVSLAE PSRPAALFSP KLQASGPYNC SLVFYHYLHG SEASCLRLFL
QTLLPSSSPA PVLLQSRCGE LGAAWVRDRV DIQSAHPFQI LLAAQTGPGG VVGLDDLILS
NHCQLVPELA ALQMLPPTPW APAPESPPSG PWFQNVCSPG HLSCGDLCVP PEQLCDFQQQ
CTGAEDEQEC GTTDFESPTA GGWEDASVGR LQWQLSAQRA ATGHFLSLQK AWGQLRPEAR
VLSPALGPSG PRCELHLAYY FLSQPRGFLA LVVVDGSSRE LVWQAPSSST GGWKVDKTLL
GARRRPFRLE FIGLLDLDGP GQQGAGVDNV TLRNCSPTET TERDREVSCN FERDTCSWYT
GHFTDAHWHR VQSHGPGYDH TTGRGHFMLL DPTEPPARDH GAYLLSQPQV PVAPIECLSF
WYHLYGPQIG TLRLLLRREG EEDTPLWSRS GTHGNRWHEA WATLHHQPHF HTQYQLLFEG
LRDGYHGTMA LDDVALRPDP CWAPKHCSFE DSGCGFFTGD QGLWKCQTNA SGQAAWGPPT
DHTTETAQGH YMVVDMSPNA LPQGHVATLT SEEYRPLAQS ACLTFWYHLS PRNPGTLRVH
MEQSGRRQVL SISAQGGAVW RLGSVGIQAG QAWRVVFEAV AAGVQPSYVA LDDLFLQDGA
CPQPGSCDFE TGLCGWSHLA WPGLSGYSWD WSSGTTPSRY PHPSVDHTLG TEAGHFAFFE
TGVLGPGGQV AWLRSEPLPA TQASCLRFWY HMGFPEHFYK GELRVLLAST QGQLAVWGQG
GHRRHQWLEA QVEVASTEEF QIVFEATLSG QPALGPIALD DVEYQAGHHC QVPTPSQGHA
AMPGSVPAAV SGALLLFMLL VLLGLGGWLW LQKTGGCPFW SNREPVTSGF DNILFNADHV
TLPASVTNDP
//