ID H0XGA2_OTOGA Unreviewed; 496 AA.
AC H0XGA2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Transmembrane protein 104 {ECO:0000313|Ensembl:ENSOGAP00000015098.2};
GN Name=TMEM104 {ECO:0000313|Ensembl:ENSOGAP00000015098.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015098.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000015098.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM104 family.
CC {ECO:0000256|ARBA:ARBA00038166}.
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DR EMBL; AAQR03041620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03041621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03041622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03041623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03041624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03041625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03041626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003786204.1; XM_003786156.2.
DR AlphaFoldDB; H0XGA2; -.
DR STRING; 30611.ENSOGAP00000015098; -.
DR Ensembl; ENSOGAT00000016866.2; ENSOGAP00000015098.2; ENSOGAG00000016861.2.
DR GeneID; 100955429; -.
DR KEGG; oga:100955429; -.
DR CTD; 54868; -.
DR eggNOG; KOG3832; Eukaryota.
DR GeneTree; ENSGT00390000001244; -.
DR HOGENOM; CLU_025541_4_0_1; -.
DR InParanoid; H0XGA2; -.
DR OMA; RWLAFTI; -.
DR OrthoDB; 67984at2759; -.
DR TreeFam; TF314030; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR013057; AA_transpt_TM.
DR PANTHER; PTHR16189:SF0; TRANSMEMBRANE PROTEIN 104; 1.
DR PANTHER; PTHR16189; UNCHARACTERIZED; 1.
DR Pfam; PF01490; Aa_trans; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..65
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
FT DOMAIN 134..450
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
SQ SEQUENCE 496 AA; 55756 MW; E5B833DE4B481D50 CRC64;
MAGEITETGE LYSPYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV FLGFMSFVTT
TFVMEAMAAA NAQLRWKRME NHKEEEDDDS STASDSDVLI QDSYERAEKR PILSVQRRGS
PNLFEITDRV EMGQMASMFF NKVGVNLFYF CIIIYLYGDL AIYAAAVPFS LMQVTCSAIG
NDSCGMEADT KHNDTDRCWG PLRRVDAYRI YLAVFTLLLG PFTFFDVQKT KYLQILTSLM
RWIAFTVMIV LALVRIGHGH GEGHPTLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK
RHLTRLVFLD YVLILAFYSL LSFTAIFCFR GDSLMDMYTL NFARCDIVGL AAVRFFLGLF
PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRIVF PTITLVPPVL VAFCTHDLES
LVGITGAYAG TGIQYVIPAF LVYLCRKDTQ LAFGYGTVNK HRSPFRHTLW VGFVLLWALS
CFLFVTANIV LSETKL
//
