ID H0XGN3_OTOGA Unreviewed; 622 AA.
AC H0XGN3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=RAD21 cohesin complex component {ECO:0008006|Google:ProtNLM};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015247.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000015247.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May promote apoptosis. {ECO:0000256|ARBA:ARBA00043845}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere
CC {ECO:0000256|ARBA:ARBA00004584}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad21 family.
CC {ECO:0000256|ARBA:ARBA00009870}.
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DR EMBL; AAQR03010539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03010540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03010541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03010542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XGN3; -.
DR STRING; 30611.ENSOGAP00000015247; -.
DR Ensembl; ENSOGAT00000017032.2; ENSOGAP00000015247.2; ENSOGAG00000017026.2.
DR eggNOG; KOG1213; Eukaryota.
DR GeneTree; ENSGT00940000154655; -.
DR HOGENOM; CLU_015775_1_1_1; -.
DR InParanoid; H0XGN3; -.
DR OMA; EDDIMQG; -.
DR TreeFam; TF101215; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0008278; C:cohesin complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd21792; Rad21_Rec8_M_NXP1-like; 1.
DR Gene3D; 1.10.10.580; Structural maintenance of chromosome 1. Chain E; 1.
DR InterPro; IPR049589; NXP1_M-like.
DR InterPro; IPR039781; Rad21/Rec8-like.
DR InterPro; IPR006909; Rad21/Rec8_C_eu.
DR InterPro; IPR006910; Rad21_Rec8_N.
DR InterPro; IPR023093; ScpA-like_C.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12585:SF20; DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21 HOMOLOG; 1.
DR PANTHER; PTHR12585; SCC1 / RAD21 FAMILY MEMBER; 1.
DR Pfam; PF04824; Rad21_Rec8; 1.
DR Pfam; PF04825; Rad21_Rec8_N; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 1..103
FT /note="Rad21/Rec8-like protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04825"
FT DOMAIN 566..619
FT /note="Rad21/Rec8-like protein C-terminal eukaryotic"
FT /evidence="ECO:0000259|Pfam:PF04824"
FT REGION 414..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..538
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 71369 MW; 8BDDDF50FC872E9A CRC64;
MFYAHFVLSK RGPLAKIWLA AHWDKKLTKA HVFECNLESS VESIISPKVK MALRTSGHLL
LGVVRIYHRK AKYLLADCNE AFIKIKMAFR PGVVDLPEEN REAAYNAITL PEEFHDFDQP
LPDLDDIDVA QQFSLNQSRV EEITMREEVG NISILQENDF DMREGSAFED DDMLVSTSDS
NLLLEPEQST SNLNEKINHL EYEDQYKDDN FGEGNDVEPM PTMTDQTTLV PNEEEAFALE
PIDITGEQIN LNLYNAEHKV LHDYLTFLLG SVCSKAKDTI RPSPIAVLWW PLKKMTLFSF
ILPVKETKAK RKRKLIVDSV KELDSKTIRA QLSDYSDIVT TLDLAPPTKK LMMWKETGGV
EKLFSLPAQP LWNNRLLKLF TRCLTPLVPE DLRKRRKGGE ADNLDEFLKE FENPEVPRED
QQQQHQQRDV IDEPILEEPS RLQESTMETS RTNLDESAMP PPPPQGVKRK AGQIDPEPVI
PPQQVEQMEI PPVELPPEEP PNICQLIPEL ELLPEKEKEK EKEKEDDEEE EDEDASGGDQ
DQEERRWNKR TQQMLHGLQR ALAKTGAESI SLLELCRNTN RKQAAAKFYS FLVLKKQQAI
ELTQEEPYSD IIATPGPRFH II
//
