ID   H0XH76_OTOGA            Unreviewed;       626 AA.
AC   H0XH76;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE            EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN   Name=TKTL2 {ECO:0000313|Ensembl:ENSOGAP00000015466.1};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015466.1, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000015466.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|ARBA:ARBA00001941};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the transketolase family.
CC       {ECO:0000256|ARBA:ARBA00007131}.
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DR   EMBL; AAQR03115407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0XH76; -.
DR   STRING; 30611.ENSOGAP00000015466; -.
DR   Ensembl; ENSOGAT00000006956.2; ENSOGAP00000015466.1; ENSOGAG00000006953.2.
DR   eggNOG; KOG0523; Eukaryota.
DR   GeneTree; ENSGT00940000161969; -.
DR   HOGENOM; CLU_009227_3_0_1; -.
DR   InParanoid; H0XH76; -.
DR   OMA; HKVYCLC; -.
DR   TreeFam; TF313097; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR   CDD; cd02012; TPP_TK; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR020826; Transketolase_BS.
DR   InterPro; IPR033248; Transketolase_C.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR43195; TRANSKETOLASE; 1.
DR   PANTHER; PTHR43195:SF4; TRANSKETOLASE-LIKE PROTEIN 2; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR   PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          319..483
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   626 AA;  67674 MW;  E84B985EEEC78C97 CRC64;
     AMADDAKPDA KTLQALRDAA NRLRIHSIRA TCASSSGHPT SCCSAAEIMS VLFFHTMRYK
     RTDPQHPDND RFVLSKGHAA PVLYAAWAEV GDISESDLLN LRKIHCDLEG HPTPRLPFVD
     VATGSLGQGL GAACGMAYTG KYFDKASYRV FCLMGDGESS EGSVWEALAF ASHYSLDNLV
     AVFDVNRLGQ SGTAPLEHCT DIYQNRCEAF GWNTYIVDGH DVEALCQAFS QAAQVKNKPT
     AIVAKTFKGR GIPNIEDAEN WHGKPVPKER AEAIIKLIQS QIQTQGNPIS KPPVEDSPQI
     SITNIQMTSP PAYKMGDKIA TQKAYGLALA KLGHENKRVI VLDSDTKNPT FSEIFKKEHP
     ERFIECFIPE QNMVSVALGC ATRGRTIVFA NTFSAFFTRA FDQIRMGAIS QTNINLIGSH
     CGVSIGEDGP SQMALEDLAM FRSIPNCTVF YPSDALSTEH AVYLAANTKG MCFIRTSQPE
     TEVIYTAQEK FEIGQAKVVL HSDNDKVTVI GAGITLHEAL AAADNLSQQG IAIRVIDPFT
     IKPLDAATII SSAKATGGRV ITVEDHHKEG GLGEAVCAAV SREPDILVHQ LAVSGLPQSG
     KPGELLDMFG ISAGHIVSAV RNILMN
//