ID H0XI62_OTOGA Unreviewed; 341 AA.
AC H0XI62;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015802.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000015802.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656}.
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DR EMBL; AAQR03079278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03079279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XI62; -.
DR STRING; 30611.ENSOGAP00000015802; -.
DR Ensembl; ENSOGAT00000030970.1; ENSOGAP00000015802.1; ENSOGAG00000033220.1.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00390000010056; -.
DR HOGENOM; CLU_064098_0_0_1; -.
DR InParanoid; H0XI62; -.
DR OMA; SCAWDGV; -.
DR TreeFam; TF106462; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR003942; LRDF.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF226; LEFT-RIGHT DETERMINATION FACTOR; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PRINTS; PR01427; TGFBETA4.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..341
FT /note="TGF-beta family profile domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003545009"
FT DOMAIN 216..329
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 341 AA; 38019 MW; 82AE437AB256E562 CRC64;
MCPLWLCWAL WMLSLAGPGA ALTEEQLLGS LLQQLHLSEV PVLEKVDVGE LAIPAHVRAQ
YVALLQRSHG DRSRGKRFSQ NFRDAAGASH LPRAGSHLLR PCGVSGEIRM LVLNRQQRPS
GQPVPVPAPH RAVSATVSCL RLVWVHESGW KTFDVIEAVN FWQQLSRPLQ PLLLQVSVQR
EHLGPQASSA HKLVRFSWQG ALGARHAEPQ LELHTLDLKD YGAQGDCDPD VPVTESTRCC
RQMYIDLQGM KWAENWVLEP LGFLAFECVG TCQQLPEPLT SKWPFLGLRQ CIPSEVASLP
VIISIREGDR TRPQVVSLPN MRVQKYDCAS DGTLVPRRLE P
//
