ID H0XIE3_OTOGA Unreviewed; 387 AA.
AC H0XIE3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Cyclase associated actin cytoskeleton regulatory protein 2 {ECO:0000313|Ensembl:ENSOGAP00000015883.1};
GN Name=CAP2 {ECO:0000313|Ensembl:ENSOGAP00000015883.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000015883.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000015883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}.
CC -!- SIMILARITY: Belongs to the CAP family. {ECO:0000256|ARBA:ARBA00007659}.
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DR EMBL; AAQR03055890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03055894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XIE3; -.
DR STRING; 30611.ENSOGAP00000015883; -.
DR Ensembl; ENSOGAT00000031360.1; ENSOGAP00000015883.1; ENSOGAG00000027194.1.
DR eggNOG; KOG2675; Eukaryota.
DR GeneTree; ENSGT00390000017955; -.
DR HOGENOM; CLU_015780_1_1_1; -.
DR InParanoid; H0XIE3; -.
DR OMA; HEDRNDL; -.
DR TreeFam; TF313791; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0099140; P:presynaptic actin cytoskeleton organization; IEA:Ensembl.
DR Gene3D; 2.160.20.70; -; 1.
DR Gene3D; 1.25.40.330; Adenylate cyclase-associated CAP, N-terminal domain; 1.
DR InterPro; IPR001837; Adenylate_cyclase-assoc_CAP.
DR InterPro; IPR013912; Adenylate_cyclase-assoc_CAP_C.
DR InterPro; IPR017901; C-CAP_CF_C-like.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR036223; CAP_C_sf.
DR InterPro; IPR028417; CAP_CS_C.
DR InterPro; IPR036222; CAP_N_sf.
DR InterPro; IPR006599; CARP_motif.
DR PANTHER; PTHR10652; ADENYLYL CYCLASE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR10652:SF2; ADENYLYL CYCLASE-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF08603; CAP_C; 1.
DR SMART; SM00673; CARP; 2.
DR SUPFAM; SSF69340; C-terminal domain of adenylylcyclase associated protein; 1.
DR SUPFAM; SSF101278; N-terminal domain of adenylylcyclase associated protein, CAP; 1.
DR PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
DR PROSITE; PS01089; CAP_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 222..365
FT /note="C-CAP/cofactor C-like"
FT /evidence="ECO:0000259|PROSITE:PS51329"
FT REGION 127..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 43127 MW; 4E45772BEECA519E CRC64;
RCDVCLQNEV ATLLKPISEK IQEIQTFRER NRGSNMFNHL SAVSESIPAL GWIAVSPKPG
PYVKEMNDAA TFYTNRVLKD YKHSDLRHVD WVKSYLNIWS ELQAYIKEHH TTGLTWSKTG
PVASGASAFS VLSSGPGPSP PPPPPPPPGP PPLFENEGRK EESSPSRSAL FAQLNQGEAI
TKDIRIICIL KNAVKLPNLC AHAFLPCTDN KELGIPYSPY TPTGKPYTFR RCLSNDLAIR
KEFLEYQEDR NDLVISETEL KQVAYIFKCD KSTLQIKGKV NSITIDNCKK FGLVFDNVVG
IVEVINSRDI QIQVMGRVPT ISINKTEGCH IYLSEDALDC AIVSAKSSEM NILIPQDGDY
REFPVPEQFK TAWDGSKLVT EPAEIMA
//
