ID H0XK99_OTOGA Unreviewed; 562 AA.
AC H0XK99;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN Name=LOC100941862 {ECO:0000313|Ensembl:ENSOGAP00000016539.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016539.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016539.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR EMBL; AAQR03192641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03192642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000016539; -.
DR Ensembl; ENSOGAT00000033127.1; ENSOGAP00000017250.1; ENSOGAG00000025210.1.
DR Ensembl; ENSOGAT00000034292.1; ENSOGAP00000016539.1; ENSOGAG00000030873.1.
DR eggNOG; ENOG502QUFB; Eukaryota.
DR GeneTree; ENSGT00950000183008; -.
DR HOGENOM; CLU_012582_1_0_1; -.
DR OMA; LHNEYEG; -.
DR TreeFam; TF328782; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11571; FAT-like_EFS_C; 1.
DR CDD; cd12003; SH3_EFS; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR035747; EFS_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF14; EMBRYONAL FYN-ASSOCIATED SUBSTRATE; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 5..68
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 69..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..87
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..123
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..326
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 58975 MW; 76CEC61F52D7879F CRC64;
SHLTHQAQLA RALYDNTAES PQELSFRRGD VLRVLQQEGA GGLDGWCLCS LHGQQGIVPA
NRVKLLPAGP APKPSLSPVP PSPQPSSSYP VLDHGKEEQE VYVVPPPARL CPASGPPAGS
SPPSPDSIYK IPRSSGTQLA ASGDILEVYD VPPTALRVPS NGPYDCPISF SYPLARAAPK
SPGEDEAFYD VPLALKPSAE LEPDVEWEGG REPGPPLYAA PSNLKRASAL LNLYEAPEEL
LADGEGGGTD EGIYDVPLLG PEAPPSPEPS GASTSKDLDT LGQLLARSPP PPHRPRLPST
ESLSRRPLPA LPVPEASSPS PAPSPAPGRK GSIQDRPLPP PPPRLPGYGG PKVEGDPEDR
EVGDDPAGHH NEYEGIPVAE EYDYVHLKGM DKAQGSRPLD KTSTGDPELL EKGLPVQQEA
LSPGEPLVLS TADLQLLHFY AGQCQSHYST LQTAVSALMS STQTNQPPRL FVPHGKRVVV
AAHRLVFVGD TLGRLVASAP LRAQVGAAGT ALGQALRATV LAVKGAALGY PSGPAAQEME
QCVVELASQA LRFTTLLTSL AS
//
