ID H0XKR6_OTOGA Unreviewed; 434 AA.
AC H0XKR6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=C-terminal binding protein 2 {ECO:0008006|Google:ProtNLM};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016706.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016706.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; AAQR03001214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XKR6; -.
DR STRING; 30611.ENSOGAP00000016706; -.
DR Ensembl; ENSOGAT00000032727.1; ENSOGAP00000016706.1; ENSOGAG00000033848.1.
DR eggNOG; KOG0067; Eukaryota.
DR GeneTree; ENSGT00940000154430; -.
DR HOGENOM; CLU_019796_1_3_1; -.
DR InParanoid; H0XKR6; -.
DR TreeFam; TF313593; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd05299; CtBP_dh; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR043322; CtBP.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR46029; C-TERMINAL-BINDING PROTEIN; 1.
DR PANTHER; PTHR46029:SF3; C-TERMINAL-BINDING PROTEIN 2; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 47..352
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 140..323
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT REGION 413..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 47792 MW; E57ABFE24D7801F5 CRC64;
MALVDNHKVK RQCLNRICEG NRPQIMNGPL HPRPLVALLD GRDCTVERLI LKDLATMAFC
DAQSTQEIHE KVLNEAVGAM MYHTITLTRQ DLEKFKALRV IVRIGSGYDN VDIKAAGELG
IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQELREGM RVQSVEQIRE VASGAARIRG
ETLGLVGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERP LGVQRVYTLQ DLLYESDCVS
LHCSLSEHNH HLINDFTIKQ MRQGAFLVNV AHGSLVDEKA LAQALKEGRI QGAALDVHES
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAAME IWRAITGRIP ESLGNCVNKE
FFARSAIDQQ AIHPELSGAT YRYPPGILGV VPGRLPAAME GIIPGGIPVT DDLPSVAHPS
QVPSSNQPTK LRDN
//
