ID H0XL93_OTOGA Unreviewed; 560 AA.
AC H0XL93;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Anti-Muellerian hormone type-2 receptor {ECO:0000256|PIRNR:PIRNR037392};
DE EC=2.7.11.30 {ECO:0000256|PIRNR:PIRNR037392};
DE AltName: Full=Anti-Muellerian hormone type II receptor {ECO:0000256|PIRNR:PIRNR037392};
DE AltName: Full=MIS type II receptor {ECO:0000256|PIRNR:PIRNR037392};
GN Name=AMHR2 {ECO:0000313|Ensembl:ENSOGAP00000016883.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016883.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: On ligand binding, forms a receptor complex consisting of two
CC type II and two type I transmembrane serine/threonine kinases. Type II
CC receptors phosphorylate and activate type I receptors which
CC autophosphorylate, then bind and activate SMAD transcriptional
CC regulators. Receptor for anti-Muellerian hormone.
CC {ECO:0000256|PIRNR:PIRNR037392}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-
CC L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA-
CC COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977,
CC ChEBI:CHEBI:456216; EC=2.7.11.30;
CC Evidence={ECO:0000256|PIRNR:PIRNR037392};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRNR:PIRNR037392};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|PIRNR:PIRNR037392};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|PIRNR:PIRNR037392}; Single-
CC pass type I membrane protein {ECO:0000256|PIRNR:PIRNR037392}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. TGFB receptor subfamily.
CC {ECO:0000256|ARBA:ARBA00009605, ECO:0000256|PIRNR:PIRNR037392}.
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DR EMBL; AAQR03076611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03076612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XL93; -.
DR STRING; 30611.ENSOGAP00000016883; -.
DR Ensembl; ENSOGAT00000029556.1; ENSOGAP00000016883.1; ENSOGAG00000028440.1.
DR eggNOG; KOG3653; Eukaryota.
DR GeneTree; ENSGT00940000160885; -.
DR HOGENOM; CLU_000288_8_4_1; -.
DR InParanoid; H0XL93; -.
DR OMA; RCPDLWP; -.
DR TreeFam; TF314724; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:1990272; F:anti-Mullerian hormone receptor activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042562; F:hormone binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0005026; F:transforming growth factor beta receptor activity, type II; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007548; P:sex differentiation; IEA:Ensembl.
DR Gene3D; 2.10.60.10; CD59; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015771; Anti-muellerian_hrmn_rcpt_II.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR000333; TGFB_receptor.
DR PANTHER; PTHR23255:SF49; ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR; 1.
DR PANTHER; PTHR23255; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF037392; AMHRII; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037392};
KW Kinase {ECO:0000256|PIRNR:PIRNR037392};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|PIRNR:PIRNR037392};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|PIRNR:PIRNR037392};
KW Membrane {ECO:0000256|PIRNR:PIRNR037392, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR037392};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037392}; Receptor {ECO:0000256|PIRNR:PIRNR037392};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000256|PIRNR:PIRNR037392}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|PIRNR:PIRNR037392};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 145..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..506
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 560 AA; 60980 MW; 7C4915F4781360F9 CRC64;
MLGSLGLWAL RPTAVQAPPN RRTCVFFEAP GVRGSTKTLG ELLGTGPGPP RVIRCLYSHC
CFGIWNLTQD QAQVEMQGCR DSDEPGCEAL HCEPTPRAHP SPGSTLFTCS CGTDFCNANY
SHLPPPGSPG TPGAQGPQAS PGESIWMALV LLGLFLLLLL LLGSIILVLL QRKACRVQGG
PEPEPDSGRD WSEELPELPE LCFSQVIQEG GHTVVWAGRL RGELVAIKAF PARAVAQFRA
ERALYELPGL QHDHIVRFIT ASRGGPSPLL SGPLLVLELH PKGSLCHYLT QHTNDWGSSL
RMALSLAQGL AFLHEERWQD GQYKPGIAHR DLSSQNVLIR EDGSCAIGDL GLALVLPGLT
QPSAWAPTQL QGPAAIMEAG TQRYMAPELL DKTLDLQDWG TALRRADIYS LALLLWEILS
RCPDLRPDSR PPPFQLAYEA ELGSTPTTCE LWTLAVEERR RPYIPSTWCC FVTDPGGLRE
LLEDCWDADP EARLTAECVQ QRLAALACPP EVPSFPESSP HSCPPLCPED CTLPPSPAIS
PMGFRKPKNK TVQQGSCCRN
//
