ID H0XLH3_OTOGA Unreviewed; 495 AA.
AC H0XLH3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Reduced folate transporter {ECO:0000256|PIRNR:PIRNR028739};
DE AltName: Full=Solute carrier family 19 member 1 {ECO:0000256|PIRNR:PIRNR028739};
GN Name=SLC19A1 {ECO:0000313|Ensembl:ENSOGAP00000016963.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000016963.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000016963.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transporter that mediates the import of reduced folates.
CC {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR028739};
CC Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}. Apical
CC cell membrane {ECO:0000256|PIRNR:PIRNR028739}. Basolateral cell
CC membrane {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC ECO:0000256|PIRNR:PIRNR028739}.
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DR EMBL; AAQR03141714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03141716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XLH3; -.
DR STRING; 30611.ENSOGAP00000016963; -.
DR Ensembl; ENSOGAT00000033713.1; ENSOGAP00000016963.1; ENSOGAG00000032361.1.
DR eggNOG; KOG3810; Eukaryota.
DR GeneTree; ENSGT00950000183022; -.
DR HOGENOM; CLU_036909_2_0_1; -.
DR InParanoid; H0XLH3; -.
DR OMA; MQFMELF; -.
DR TreeFam; TF313684; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061507; F:2',3'-cyclic GMP-AMP binding; IEA:Ensembl.
DR GO; GO:0140360; F:cyclic-GMP-AMP transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0008518; F:folate:monoatomic anion antiporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005542; F:folic acid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015350; F:methotrexate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0140361; P:cyclic-GMP-AMP transmembrane import across plasma membrane; IEA:Ensembl.
DR GO; GO:1904447; P:folate import across plasma membrane; IEA:UniProtKB-UniRule.
DR CDD; cd06174; MFS; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR028339; SLC19A1.
DR NCBIfam; TIGR00806; rfc; 1.
DR PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR PANTHER; PTHR10686:SF12; REDUCED FOLATE TRANSPORTER; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR PIRSF; PIRSF028739; Folate_carrier; 1.
DR PIRSF; PIRSF500793; Folate_transporter_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|PIRNR:PIRNR028739};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR028739};
KW Folate-binding {ECO:0000256|PIRNR:PIRNR028739};
KW Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT TRANSMEM 67..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 474..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 56080 MW; 4A756279CCEC0615 CRC64;
MMPSSPEGEK QVPTEPKLDC EPQPWRCLVF YLCFYGFMAQ MRPGESFITP YLLRDKNFTQ
EQVTNEITPV LSYSYMLVLV PIFLLTDYLR YKPVLLLQGL SYTSVWLLLL FGGSVQHMQL
MEFFYSVTMA ARVAYSSYIF SLVHPARYQR MAGYSRAAVL LGVFTSSVLG QLLVSTGRVS
FRTLNYISLA FLIFSLLLAS FLKRPKRSLF FNRSSTPLRG AVPSELQPVR PGPAPRGKLL
AACRDCILVR MLHELGASLR LPQLRLWSLW WVLNSAGYYL VVYYVHILWN TLCPTTDSAQ
VYNGAADAAS TLLGAMTSFA AGFVKIRWAL WSKLVIACVT AAQAGLIFLL YNVVSIWPCY
GAFVLFRGFY QFLVPIATFQ IASSLSKELC ALVFGINTFF ATILKTIITL IVSDKRGLGL
PVWSQFRIYF VYFLVLSIFY FLGAMLDGWR HFQRSHHRPL PLAQELRSPL EEKAEQTPSM
QDTCPPLYPE GSAWG
//
