ID H0XMF1_OTOGA Unreviewed; 334 AA.
AC H0XMF1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Transcription factor Jun {ECO:0000256|ARBA:ARBA00029507};
DE AltName: Full=Activator protein 1 {ECO:0000256|ARBA:ARBA00030713};
DE AltName: Full=Proto-oncogene c-Jun {ECO:0000256|ARBA:ARBA00031819};
DE AltName: Full=Transcription factor AP-1 subunit Jun {ECO:0000256|ARBA:ARBA00032537};
DE AltName: Full=V-jun avian sarcoma virus 17 oncogene homolog {ECO:0000256|ARBA:ARBA00029919};
GN Name=JUN {ECO:0000313|Ensembl:ENSOGAP00000017292.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000017292.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000017292.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the bZIP family. Jun subfamily.
CC {ECO:0000256|ARBA:ARBA00006882}.
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DR EMBL; AAQR03100441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003793174.1; XM_003793126.2.
DR AlphaFoldDB; H0XMF1; -.
DR STRING; 30611.ENSOGAP00000017292; -.
DR Ensembl; ENSOGAT00000005605.2; ENSOGAP00000017292.1; ENSOGAG00000005602.2.
DR GeneID; 100965098; -.
DR KEGG; oga:100965098; -.
DR CTD; 3725; -.
DR eggNOG; KOG0837; Eukaryota.
DR GeneTree; ENSGT00940000162061; -.
DR HOGENOM; CLU_057007_0_0_1; -.
DR InParanoid; H0XMF1; -.
DR OMA; HHQHMPA; -.
DR OrthoDB; 4493275at2759; -.
DR TreeFam; TF323952; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035976; C:transcription factor AP-1 complex; IEA:Ensembl.
DR GO; GO:0035497; F:cAMP response element binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0140296; F:general transcription initiation factor binding; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
DR GO; GO:0034614; P:cellular response to reactive oxygen species; IEA:Ensembl.
DR GO; GO:0043922; P:negative regulation by host of viral transcription; IEA:Ensembl.
DR GO; GO:0043923; P:positive regulation by host of viral transcription; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:2000144; P:positive regulation of DNA-templated transcription initiation; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0019046; P:release from viral latency; IEA:Ensembl.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd14696; bZIP_Jun; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR005643; JNK.
DR InterPro; IPR002112; Leuzip_Jun.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR PANTHER; PTHR11462; JUN TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR11462:SF8; TRANSCRIPTION FACTOR JUN; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF03957; Jun; 1.
DR PRINTS; PR00043; LEUZIPPRJUN.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 255..318
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT COILED 260..321
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 334 AA; 35950 MW; 920A96C2243C46A5 CRC64;
MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE
LHSQNTLPSV TSAAQPVSGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA
LSSGGGAPSY GAAGLAFPAQ PQQQQQAPQP PHHLPQQMPV QHPRLQALKE EPQTVPEMPG
ETPPLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST
ANMLREQVAQ LKQKVMNHVN SGCQLMLTQQ LQTF
//
