ID H0XPK4_OTOGA Unreviewed; 806 AA.
AC H0XPK4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Tripartite motif containing 28 {ECO:0000313|Ensembl:ENSOGAP00000018045.1};
GN Name=TRIM28 {ECO:0000313|Ensembl:ENSOGAP00000018045.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018045.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03119250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03119251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XPK4; -.
DR STRING; 30611.ENSOGAP00000018045; -.
DR Ensembl; ENSOGAT00000032015.1; ENSOGAP00000018045.1; ENSOGAG00000033160.1.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160527; -.
DR HOGENOM; CLU_005817_2_0_1; -.
DR InParanoid; H0XPK4; -.
DR OMA; DCKDEVP; -.
DR TreeFam; TF106455; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0070087; F:chromo shadow domain binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0035851; F:Krueppel-associated box domain binding; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
DR GO; GO:0006281; P:DNA repair; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR GO; GO:0060669; P:embryonic placenta morphogenesis; IEA:Ensembl.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0071514; P:genomic imprinting; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:1901536; P:negative regulation of DNA demethylation; IEA:Ensembl.
DR GO; GO:0045869; P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0090309; P:positive regulation of DNA methylation-dependent heterochromatin formation; IEA:Ensembl.
DR GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0043045; P:post-fertilization epigenetic regulation of gene expression; IEA:Ensembl.
DR GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR GO; GO:0044790; P:suppression of viral release by host; IEA:Ensembl.
DR CDD; cd19846; Bbox1_TIF1b_C-VI; 1.
DR CDD; cd19829; Bbox2_TIF1b_C-VI; 1.
DR CDD; cd05502; Bromo_tif1_like; 1.
DR CDD; cd15623; PHD_TIF1beta; 1.
DR CDD; cd16765; RING-HC_TIF1beta; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR037373; KAP1.
DR InterPro; IPR047059; TIF1b_Bbox1_Znf.
DR InterPro; IPR047058; TIF1b_Bbox2_Znf.
DR InterPro; IPR042713; TIF1beta_RING-HC.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR PANTHER; PTHR45915:SF9; TRIPARTITE MOTIF CONTAINING 28; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00643; zf-B_box; 2.
DR Pfam; PF14634; zf-RING_5; 1.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 34..90
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 117..164
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 173..214
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 596..643
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 86691 MW; CCAE1075C33380A6 CRC64;
RAGAPSAAQQ AATSRASAAP RARGAAAQEL LEHCGVCRER LRPEREPRLL PCLHSACSAC
LGPAAPAAAN SSGDGGAAGD SAVVDCPVCK QQCFSRDIVE NYFMRDSGSK AATDAQDANQ
CCTSCEDNAP ATSYCVECSE PLCETCVEAH QRVKYTKDHT VRSTGPAKSR DGERTVYCNV
HKHEPLVLFC ESCDTLTCRD CQLNAHKDHQ YQFLEDAVRN QRKLLASLVK RLGDKHATLQ
KSTKEVRSSI RQVSDVQKRV QVDVKMAILQ IMKELNKRGR VLVNDAQKVT EGQQERLERQ
HWTMTKIQKH QEHILRFASW ALESDNNTAL LLSKKLIYFQ LHRALKMIVD PVEPHGEMKF
QWDLNAWTKS AEAFGKIVAE RPGTNSTGPA PMAPPRAPGT LSKQGSGSGQ PMEVQEGYGF
GSVLYADDPY SSAEPHVSGV KRSRSGEGEV SGLMRKVPRV SLERLDLDLT ADSQPPVFKV
FPGSTTEDYN LIVIERGAAA AAAGQPGTAP PGTPGAPPLP GMAIVKEEET EAAIGAPPAT
EGPETKPVLV ALSEGPSAEG PRLASPSGST SSGLEVVAPE GTSAPGGGPG TLDDSATICR
VCQKPGDLVM CNQCEFCFHL DCHLPALQDV PGEEWSCSLC HVLPDLKEED GNLSLDAADS
SGVVAKLSPA NQRKCERVLL ALFCHEPCRP LHQLATDSTF SLDQPGGTLD LTLIRARLQE
KLSPPYSSPQ EFAQDVGRMF KQFNKLTEDK ADVQSIIGLQ RFFETRMNEA FGDTKFSAVL
VEPPPLSLPS AGLSSQELSG GPGDGP
//
