ID H0XPK7_OTOGA Unreviewed; 1034 AA.
AC H0XPK7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Myosin IH {ECO:0000313|Ensembl:ENSOGAP00000018048.1};
GN Name=MYO1H {ECO:0000313|Ensembl:ENSOGAP00000018048.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018048.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018048.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AAQR03070133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03070136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XPK7; -.
DR STRING; 30611.ENSOGAP00000018048; -.
DR Ensembl; ENSOGAT00000029510.1; ENSOGAP00000018048.1; ENSOGAG00000029542.1.
DR eggNOG; KOG0164; Eukaryota.
DR GeneTree; ENSGT00940000156430; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR InParanoid; H0XPK7; -.
DR OMA; MEIYQGV; -.
DR TreeFam; TF312960; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF353; UNCONVENTIONAL MYOSIN-IH; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 16..702
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 856..1030
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 577..599
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 109..116
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1034 AA; 119380 MW; F91B0BC7D047C4FC CRC64;
IRLHMEGTLT ARDKVGVQDF VLLDAYTSES AFVDNLRKRF SENLIYTYIG TLLVSVNPYQ
ELGIYTMSQM ELYQGVNFFE LPPHVYAIAD NAYRMMCSEL NNHFILISGE SGAGKTEASK
KILQYFAVTC PMTQSLQIAR DRLLLSNPVL EAFGNAKTLR NDNSSRFGKY MDIQFDFQGI
PVGGHIISYL IEKSRVVYQN HGERNFHIFY QLLAGGEEER LAYLGLERDP QLYKYLSQGH
CAKESSINDK NDWKTVSNAF SVIDFTEGDL ENLFGIIASV LHLGNVGFEG DDQGCATIPD
THEIKWIAKL LGVHSSILLE ALTHRKIEAK TEEVICPLTL ELSVYARDAM AKAVYGRTFT
WLVNKINSSL VNKGINTIDF TKKTVIGLLD IYGFEVFDKN GFEQFCINYC NEKLQQLLIE
RTLKAEQTEY EMEGIEWEPI QYFNNKIICD LVEERHKGII SILDEECIRP GPATDLSFLE
KLEEKVGKHA HFETRKLAGP KGRKRIGWME FRLLHYAGEV TYCTKGFLEK NNDLLYRHLK
EVLCKSTNSI LRECFLVAEL ENRRRPPTVG TQFKNSLSSL LEILISKEPS YIRCIKPNER
KEPSKFDDFL VRHQIKYLGL MEHLRVRRAG FAYRRKYEHF LQRYKSLCPD TWPHWCGPPA
EGVERLIKYI GYKPEEYKLG NSRTKIFIRF PRTLFATEDA FEFSKHQLVA RIQATYKGCQ
ERREYARKRQ AAIKLETYWR GALARREAER RKWAVQIIRK FIKGFIYRNK PLCPDNEEFV
VFVRKNYILN LRYHIPKTVL DRSWLRPPGI LESASDLLRK MCTRNLVRKY CRGITVECKA
MMQQKVVTSE IFRGKKEGYA ESLKQPFANS RIDEEDINPK VLQLIGHEKI QYGIPVIKYD
RKGFKARQRQ LILTQKAAYV VELAKIKQKI EYSALKGVST SNLSDGILVI HVSPEDNKQK
GDVVLQCEHV FEAVTKLIML VKKENIVNVV QGSLQFYISP GKEGTIAFNT GPEEQVYKDK
NGQLTVVSGC VWRE
//
