ID   H0XQT8_OTOGA            Unreviewed;       481 AA.
AC   H0XQT8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Keratin, type II cytoskeletal 8 {ECO:0000256|ARBA:ARBA00039429};
DE   AltName: Full=Cytokeratin-8 {ECO:0000256|ARBA:ARBA00042964};
DE   AltName: Full=Keratin-8 {ECO:0000256|ARBA:ARBA00042886};
DE   AltName: Full=Type-II keratin Kb8 {ECO:0000256|ARBA:ARBA00043133};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018480.1, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000018480.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Together with KRT19, helps to link the contractile apparatus
CC       to dystrophin at the costameres of striated muscle.
CC       {ECO:0000256|ARBA:ARBA00037766}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AAQR03124958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0XQT8; -.
DR   STRING; 30611.ENSOGAP00000018480; -.
DR   Ensembl; ENSOGAT00000029703.1; ENSOGAP00000018480.1; ENSOGAG00000026264.1.
DR   eggNOG; ENOG502QURK; Eukaryota.
DR   GeneTree; ENSGT00940000153339; -.
DR   HOGENOM; CLU_012560_5_4_1; -.
DR   InParanoid; H0XQT8; -.
DR   OMA; NMDSTIT; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF26; KERATIN, TYPE II CYTOSKELETAL 8; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          99..400
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          103..137
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          305..378
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   481 AA;  52807 MW;  34BC715C8710644B CRC64;
     KSPAQTAKTT MMATSVCIHP TGFSSCSYSS GPGACISSSF SWVGSGSFPS GLGTGLCLGG
     GYARAGGMGG ITAVTVNQNL LSPLNLEVDP NIQAMCPQEK EEIKTLNNKF ASFIDKVRFL
     EQRNKMLETR WNLLQQQKTA HSNMDSLCES YINKLPRQLD TLGQEKLKLE AELGNMQGLV
     EDFKNKYEEI NKTEMENESV LIRKDVDEGW VELESRLDGL TDEISFLRLL YEEEIRELQS
     QISDMSVVLS MDNSRSLMDS IIAEVRSQYE GIAIHSWAEA ESVYQTKYKE LQMQAGKHGR
     TKTEISNMNL NISRLQNETE ALQGQRAAVE ASIADAKQHR ELAVKDANAK LAQLEAALGQ
     AKQDIAQQLR EYQDLMNVKL ALDVEITTYH KLLEGKESQL ESGMQNLSIH TKTTSGYSGG
     LSSAYGGLTS LGLSYGLSSF QTVFGSGGGS SSFSHTQAVV VKKIETRDGK LVSESFDVPP
     K
//