ID H0XRI1_OTOGA Unreviewed; 180 AA.
AC H0XRI1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=DAN domain BMP antagonist family member 5 {ECO:0000313|Ensembl:ENSOGAP00000018723.1};
GN Name=DAND5 {ECO:0000313|Ensembl:ENSOGAP00000018723.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018723.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018723.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR027807}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|PIRNR:PIRNR027807}.
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DR EMBL; AAQR03140476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012665581.1; XM_012810127.1.
DR AlphaFoldDB; H0XRI1; -.
DR STRING; 30611.ENSOGAP00000018723; -.
DR Ensembl; ENSOGAT00000034457.1; ENSOGAP00000018723.1; ENSOGAG00000026803.1.
DR GeneID; 100952762; -.
DR KEGG; oga:100952762; -.
DR CTD; 199699; -.
DR eggNOG; ENOG502RZ3T; Eukaryota.
DR GeneTree; ENSGT00530000063926; -.
DR HOGENOM; CLU_122900_0_0_1; -.
DR InParanoid; H0XRI1; -.
DR OMA; PVVLWCR; -.
DR OrthoDB; 5347549at2759; -.
DR TreeFam; TF106445; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016015; F:morphogen activity; IEA:Ensembl.
DR GO; GO:0003283; P:atrial septum development; IEA:Ensembl.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; IEA:Ensembl.
DR GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0038101; P:sequestering of nodal from receptor via nodal binding; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR016860; Cerberus.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15273; DAN DOMAIN FAMILY MEMBER 5; 1.
DR PANTHER; PTHR15273:SF5; DAN DOMAIN FAMILY MEMBER 5; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF027807; Cerberus; 2.
DR SMART; SM00041; CT; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR027807};
KW Signal {ECO:0000256|PIRNR:PIRNR027807}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT CHAIN 22..180
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT /id="PRO_5024527915"
FT DOMAIN 94..180
FT /note="CTCK"
FT /evidence="ECO:0000259|SMART:SM00041"
SQ SEQUENCE 180 AA; 19684 MW; 17D4ECA24A71DDB2 CRC64;
MFLSRLATLL SLLSGVPLLT GSGMPGPHPW AAANRTWALE PLVTAPSLSS WKTFLGLQKT
RRQQIGSLKP RQKVATAMSL PLDPQELTQE MCKAVPFIQV VSRPGCTATH LRNHLCFGRC
SSLYIPSSDA TPIVLCNSCV PSQKRWASMA LWCHAGSPAT RWRVKISTML IEGCRCSPKV
//
