ID H0XS19_OTOGA Unreviewed; 634 AA.
AC H0XS19;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN Name=GLB1L3 {ECO:0000313|Ensembl:ENSOGAP00000018911.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000018911.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000018911.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|RuleBase:RU000675};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR EMBL; AAQR03123549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XS19; -.
DR STRING; 30611.ENSOGAP00000018911; -.
DR Ensembl; ENSOGAT00000030019.1; ENSOGAP00000018911.1; ENSOGAG00000030956.1.
DR eggNOG; KOG0496; Eukaryota.
DR GeneTree; ENSGT00950000182942; -.
DR HOGENOM; CLU_007853_7_2_1; -.
DR InParanoid; H0XS19; -.
DR OMA; ILIMEYW; -.
DR TreeFam; TF354299; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR019801; Glyco_hydro_35_CS.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR PANTHER; PTHR23421:SF59; BETA-GALACTOSIDASE-1-LIKE PROTEIN 3; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000675};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000675};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 61..372
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 430..529
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 553..612
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 208
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 282
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 634 AA; 72850 MW; 3CA3860E87408048 CRC64;
LGIFFLPFIL PNFARRINHL SSLSLSPSPF RYNFSHLTPL QLKNRSVGLK TKSTGWTKPY
FTLEGHKFLI FGGSIHYFRV PREYWQDRLL KLKACGFNTV TTYVPWNLHE PQRGKFDFSE
NLDLEAFVLL AAEIGLWVIL RPGPYICSEI DLGGLPSWLL QDPELKLRTT SPGFLEAVDK
YFDHLIPRVI PLQYSQGGPV IALQVENEYG AYAQDVKYMP YLHKTLLQRG IVELLLTSDG
EKEVLKGHIK GVLATVNLKK LRKNAFSQLY EVQRGKPLLI MEFWVGWFDR WGESHHITNA
DNLEYNVSKL IKHEISFNLY MFHGGTNFGF MNGASYMGRH VSVVTSYDYD AVLTEAGDYT
EKYFKLRKLL ENVSVTPLPS LPKPTLPAVY PPVKPSLYLP LWDVLSYLNE PVKLNQPVNM
ENLPINNGSG QSYGFVLYET RICSGGFLWA HAHDIAEVFL NETIIGFLNE AVRGLRIPQF
RDCQLLRILV ENQGRINYSW KMQNEQKGLT GSVTINNITL ENFTIYSLEM KTSFFERLRS
ATWRPVPLRY LGPAFYRGTL KAGSSPKDTF LRLQNWHYGF VFINGQNLGR YWNIGPQRTL
YLPGTWLHPE DNEIIVFEKI MSGSDIQSTD KPML
//