GenomeNet

Database: UniProt
Entry: H0XSM3_OTOGA
LinkDB: H0XSM3_OTOGA
Original site: H0XSM3_OTOGA 
ID   H0XSM3_OTOGA            Unreviewed;       395 AA.
AC   H0XSM3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-OCT-2019, entry version 43.
DE   RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN   Name=NHLRC1 {ECO:0000313|Ensembl:ENSOGAP00000019115};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000019115, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000019115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000019115}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AAQR03055938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003788373.1; XM_003788325.2.
DR   STRING; 30611.ENSOGAP00000019115; -.
DR   Ensembl; ENSOGAT00000007740; ENSOGAP00000019115; ENSOGAG00000007737.
DR   GeneID; 100966878; -.
DR   CTD; 378884; -.
DR   eggNOG; ENOG410ITF2; Eukaryota.
DR   eggNOG; ENOG410ZMHC; LUCA.
DR   GeneTree; ENSGT00730000111361; -.
DR   InParanoid; H0XSM3; -.
DR   OMA; WGTLINP; -.
DR   OrthoDB; 711255at2759; -.
DR   TreeFam; TF331018; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:Ensembl.
DR   GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR   Gene3D; 2.120.10.30; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51125; NHL; 6.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   DOMAIN       26     72       RING-type. {ECO:0000259|PROSITE:PS50089}.
FT   REPEAT      113    157       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      161    204       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      205    245       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      248    300       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      325    349       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      350    393       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
SQ   SEQUENCE   395 AA;  42315 MW;  F6A98373396DCF45 CRC64;
     MGAEASESGP ALRELVREAE TSLLECKVCF ERFGHRQQRR PRNLPCGHVV CLACVAALAH
     PRTLALECPF CRRACRGCDT SDCLPVLHLL ELLGSALHPS PAAPRSAPCA PGALTCHHAF
     GGWGTLVNPT GLALCPKTGR VVVVHDARRR VKIFDSGGGC AHQFGEKGDA AQDIRYPLDV
     TVTNDCHVVV TDAGDRSIKV FDFFGQIKLV IGSQFSLPWG VDTTPQNGVV VTDAEAGSLH
     LLEVDFAEGV LRRTERLQAH LCNPRGVAVC WLNGAIAILE HPMALGTGAC STKVKVFSSA
     MQLIGQVDTF GLSLFFPSKI TASAVTFDHQ GNVIIADTSG PSIFCLGKPE EFPVLKPMVT
     HGLTHPVALT FTKENSLLVL DTASHSIKVY KVDWG
//
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