ID H0XSU2_OTOGA Unreviewed; 856 AA.
AC H0XSU2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=A-kinase anchoring protein 4 {ECO:0000313|Ensembl:ENSOGAP00000019184.1};
GN Name=AKAP4 {ECO:0000313|Ensembl:ENSOGAP00000019184.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000019184.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000019184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AKAP110 family.
CC {ECO:0000256|ARBA:ARBA00005764}.
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DR EMBL; AAQR03154595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XSU2; -.
DR STRING; 30611.ENSOGAP00000019184; -.
DR Ensembl; ENSOGAT00000024637.1; ENSOGAP00000019184.1; ENSOGAG00000029364.1.
DR eggNOG; ENOG502QQXJ; Eukaryota.
DR GeneTree; ENSGT00940000153313; -.
DR HOGENOM; CLU_016756_1_0_1; -.
DR InParanoid; H0XSU2; -.
DR OMA; VMKLCMI; -.
DR TreeFam; TF105403; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0097224; C:sperm connecting piece; IEA:Ensembl.
DR GO; GO:0097229; C:sperm end piece; IEA:Ensembl.
DR GO; GO:0035686; C:sperm fibrous sheath; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0097228; C:sperm principal piece; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0051018; F:protein kinase A binding; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0045184; P:establishment of protein localization; IEA:Ensembl.
DR GO; GO:0120316; P:sperm flagellum assembly; IEA:Ensembl.
DR GO; GO:0007178; P:transmembrane receptor protein serine/threonine kinase signaling pathway; IEA:Ensembl.
DR InterPro; IPR020799; AKAP_110.
DR InterPro; IPR018292; AKAP_110_C.
DR InterPro; IPR018459; RII-bd_1.
DR InterPro; IPR008382; SPHK1-interactor_AKAP_110.
DR PANTHER; PTHR10226; A KINASE ANCHOR PROTEIN; 1.
DR PANTHER; PTHR10226:SF8; A-KINASE ANCHOR PROTEIN 4; 1.
DR Pfam; PF05716; AKAP_110; 3.
DR Pfam; PF10522; RII_binding_1; 1.
DR SMART; SM00807; AKAP_110; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 215..233
FT /note="RII binding"
FT /evidence="ECO:0000259|Pfam:PF10522"
FT DOMAIN 282..530
FT /note="A-kinase anchor 110kDa C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05716"
FT DOMAIN 525..730
FT /note="A-kinase anchor 110kDa C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05716"
FT DOMAIN 756..856
FT /note="A-kinase anchor 110kDa C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05716"
FT REGION 184..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 94274 MW; 3C33B0E6084678EB CRC64;
IIDYSDTTMM SDDIDWLHSR RGVCKVDLYS PVGQRDQDRK VICFVDVSTL NVEDKDCKDA
TGSSSDGDLS LGNLEEKEII VIKDTEKQDQ SKTEGSVCLF KQAPSDPISV FNWLLNDLQK
YALGFQHALS PSASSCKHKV GETKDEEHQM HSGNCYSVYA DQLNLNYLTN EPQSLRVEMT
AAKNTNNNQS PSSPPAKSSS GQRAVISPDG ECCMDDLSYY VNRLSSLVIQ MARKEIKDKL
EGGSKCLHHS MYPPTGDKGK NSPRSAVSKI ASEMVHDAME VSSSEMRGPG EDCKEGGRKT
FLYSELSNKN KCGEKQMCQR DSKEFADSIS KGLMVYANQV ASDMMVSVMK TLKVHSGKPI
PACVVLKRVL LKHTKEIVSD LIDSCMKNLH NITGVLMTDS DFVSAVKRNL FNHGKQNAAD
IMEAMLKRLV SALLGEKRET KSQSLSYASL KAGSQDPKCK NQSLEFSAVK AEMKGKDKCK
AKTDPCKSLT SAEKVSEHIL KESLTMWNQK QGNQGKVACA KACANKEEKR EKISPSTDSL
AKDLIVSALM LIQYHLTQQA KCKDTCEEEC PSSSVNYVAQ STQFEKCGGA QTAKAVSMKH
VESRGNPAPS TSAAAKETPQ PDCQKLDMSN IVLTLIQKLL NESPFSCEEL CEGENKRSEP
KIAKPSCMSK RSDRVEEQQC QENQDLDFLS GMKQVNRQFI DQLVESVMKL CLIMAKYSSN
GAALAELEEQ AALAGNSNFS GLKCGHDGAM SQGFDTSGPE VIVNNQCSTS NLQKQLQAVL
QWIAASQFNV PMLYFMGDDD GQLEKLPEVS AKAAEKGYSV GDLLQEVMKF AKERQLDEAV
GNMARKQLLD WLLTNL
//
