ID   H0XT48_OTOGA            Unreviewed;      1004 AA.
AC   H0XT48;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Pyrin domain-containing protein {ECO:0000259|PROSITE:PS50824};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000019290.1, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000019290.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   EMBL; AAQR03181525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03181526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03181527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0XT48; -.
DR   STRING; 30611.ENSOGAP00000019290; -.
DR   Ensembl; ENSOGAT00000025002.1; ENSOGAP00000019290.1; ENSOGAG00000031696.1.
DR   eggNOG; ENOG502QQ5H; Eukaryota.
DR   GeneTree; ENSGT00940000163635; -.
DR   HOGENOM; CLU_002274_2_1_1; -.
DR   InParanoid; H0XT48; -.
DR   OMA; MDESALC; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   PANTHER; PTHR45690:SF5; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 11; 1.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 8.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50824; DAPIN; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT   DOMAIN          1..93
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
SQ   SEQUENCE   1004 AA;  114488 MW;  1EA74D59833E4B5D CRC64;
     MAESFSAAFD LLWYLEKLSD EEFHSFKSHL EQEIQQFGLP QIPLTDLEVS KEVLVNTLRS
     SYEEQHTWNM TFSILQKLGH KDLCEKITIR QNRNKEMHKC LMRTKFLSQW ETCRFSEIHY
     SFFSEVTCDI FYILESSYDS STSSKENLNV FLVGDRATGK SMITKMAVTK WTVGEMWKAP
     IADILSDPRK VLFILEDLDN MNVDLNVDES ALCSDSRRKV PVSVLLVSLL KRKMVPGCWV
     LVSSRPSCEP SIKALMNERD CYVTLQLSNE KKQHYFHLFF NNQERAVLTF KFVLMSEILV
     DLCEVPLLSW ILCTVLNQQI NQGEDIGFSC ETPTDIYTHY LASVLASDPE VTARQHHLIL
     LNRLCLLALE GLSHNTLRFS RNDLVSVGFT SDDVSVLQAM NILLRSSNHQ VRFEFIHLNI
     QEFCAALASL MVLPRRWIPS ARRRKKEKRE LYDNFSPVVT SIFGLLNEKR RKILETSLGC
     QLPMVESLRQ NLLMQMKYLG NNPNLMEHHM PLFYCFLENL EEEFVKEIMS FFSEATIFIQ
     DNKDLMVSLY CLQHCQPLQK LKLSVQQVFR CETPISMLTS SQIRGLTFWM HICSLFYTKE
     NFRELEICTS DFNRISELLL CKALRHPNCQ LQTLRLSYVS VSSNFNDLFM SMACNQNLTF
     LNVNCIPISP KMFSLLCEAL SSPTCNIQHL SLMRCDLQAS ACPEIASILI SSKKLKKLTL
     SNNPLKNDGV KILCDALFHP ECVLESLGLY FCCLTERCVA YIARVLMFST TLKHLDLSVN
     CLQNRAVLAL TFPLSLPECH LQELELTGCF FNNEVCHYIA SSLISNVHLR RLELGYNNLG
     DAGVESLCNA LQHQDCKLET VGLEGCMLTS ACCTTLASVF SSSKTLKKLN LIENNLGDEG
     IMKLIQGLGH PSCVLELLGI GVSDLSAETQ SLLMAVREKN TKLEFSSSFS TVKEGRQFND
     LLGSGNPPEP ASTTPNYPWH SIFFKLPRKF SSMTEETTVS EQSL
//