ID H0XTP1_OTOGA Unreviewed; 827 AA.
AC H0XTP1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Family with sequence similarity 171 member A2 {ECO:0000313|Ensembl:ENSOGAP00000019483.1};
GN Name=FAM171A2 {ECO:0000313|Ensembl:ENSOGAP00000019483.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000019483.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000019483.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the FAM171 family.
CC {ECO:0000256|ARBA:ARBA00006818}.
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DR EMBL; AAQR03042482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003786316.1; XM_003786268.2.
DR AlphaFoldDB; H0XTP1; -.
DR STRING; 30611.ENSOGAP00000019483; -.
DR Ensembl; ENSOGAT00000026185.1; ENSOGAP00000019483.1; ENSOGAG00000028741.1.
DR GeneID; 100964340; -.
DR KEGG; oga:100964340; -.
DR CTD; 284069; -.
DR eggNOG; ENOG502QTDH; Eukaryota.
DR GeneTree; ENSGT00950000183184; -.
DR HOGENOM; CLU_019729_0_0_1; -.
DR InParanoid; H0XTP1; -.
DR OMA; WVIVTAS; -.
DR OrthoDB; 4211644at2759; -.
DR TreeFam; TF331338; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018890; FAM171.
DR InterPro; IPR049175; FAM171_C.
DR InterPro; IPR048530; FAM171_N.
DR PANTHER; PTHR31626:SF3; PROTEIN FAM171A2; 1.
DR PANTHER; PTHR31626; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20771; FAM171A1-2-B_C; 1.
DR Pfam; PF10577; FAM171A1-2-B_N; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..827
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003545666"
FT TRANSMEM 286..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..295
FT /note="FAM171 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10577"
FT DOMAIN 382..825
FT /note="FAM171 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20771"
FT REGION 383..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..582
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 87826 MW; C610E964B46F2BFA CRC64;
MPLPSSPSVL TRLLPLLGLL LGGASRAPGK SPPEPLSPQE ILIKVQVYVS GELVPLARAS
VDIFGNRTLL ATGTTDSEGV ATLPLSYRLG TWVLVTAARP GFLTNSVPWR VDKLPLYASV
SLYLLPERPA TLILYEDLVH ILLGSPGARS QPWVQFQRRA ARLPVSSTYS QLWASLTPAS
TQQEMRAFPA FLGTEASSSG NGSWLELMPL AAISVHLLTG NGTEVPLSGP IHLSLPVPSE
ARALAVGTSI PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTAGL
VTITSGIQDI GTYHTIFLLT ILAALALLLL ILLCLLIYYC RRRCLKPRQQ HRKLQLSGPS
DGNKRDQATS MSQLHLICAG PLEPASSGDP EAPPPGPLHS AFSSSRDLAA SRDDFFRAKP
RSASRPAAEP SGARGGEVAG LKGARSVEGP GGLEPGLEEY RRGPSGAAAF LHEPPSPPPP
FDHYLGHKGA AESKTPDFLL SQSVDQLARP PSLSQPGQLI FCGSIDHLKD NVYRNVMPTL
VIPAHYVRLS GEAGAAGVGD EPVPPEGAAP GPARPFPQPD PQRPLMQGHS GAGGEGGGGG
GGEGWGSGRS APVSGSVTIP VLFNESTMAQ LNGELQALTE KKLLELGVKP HPRAWFVSLD
GRSNSQVRHS YIDLQAGGGG RSTDASLDSG VDVHEARPTR RRAPKEERER APPAAPLPPP
APPRLALSED TEPSSSESRT GLCSPEDNSL TPLLDEVAAP EGRAATVPRG RGRSRGDSSR
SSASELRRDS LTSPEDELGA EVGDEAGDKK SPWQRREERP LMVFNVK
//
