ID H0XUT2_OTOGA Unreviewed; 632 AA.
AC H0XUT2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000019874.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000019874.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|RuleBase:RU000675};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR EMBL; AAQR03123549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XUT2; -.
DR STRING; 30611.ENSOGAP00000019874; -.
DR Ensembl; ENSOGAT00000029566.1; ENSOGAP00000019874.1; ENSOGAG00000024746.1.
DR eggNOG; KOG0496; Eukaryota.
DR GeneTree; ENSGT00950000182942; -.
DR HOGENOM; CLU_007853_7_2_1; -.
DR InParanoid; H0XUT2; -.
DR OMA; HVQDRGQ; -.
DR TreeFam; TF354299; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR019801; Glyco_hydro_35_CS.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421:SF56; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000675};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000675};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..632
FT /note="Beta-galactosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003546411"
FT DOMAIN 57..366
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 417..526
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 550..608
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
SQ SEQUENCE 632 AA; 73206 MW; 7D53909A09BC9EED CRC64;
CSMWGFLVRL EWILCLSSAL AVMANFGDNL PRINQTHLTP SQLKNRKEGL QIKGSEFTLE
GFPFRILSGT VHYFRVPRRY WWDRLLKLKA CGFNTLTTSI PWNLHEPTDN DFYFTGTRNF
EDFIHMASQV GLWVILCPGP YIGSDLDLGG LPSWLLKDQR MKLRTTYKGF TRAVNRYFDQ
LIPKVVPLQY TKGGPIIAVQ VENEYGSYNL DRRYMPYVKE ALVTRGIEVL LMTADSGPEL
RKGHIKNVLV TVHQKGVNQE TYQELASIQG ASPIMMMVYT AASFDTWGQL RKYRDPQMLK
RDVTEMFKLK FSLNFYMFHG GTNFGFMGGA TILHTYLPVV TSYDYMALLR EEGEYTPEYT
VYQEYFNSIL ELPMPLQPDR PESTSYKSVI PLHFLPLWDI LDFLELPFES IKPISMEMLP
VHQSYGYILY ETYISKDGIL YSRGHVQDRA QVFLNGQLIG VLDHSTDHLS IKKNKPYQKR
QLLRILVENQ GRLASGEDMN TQRKGLTGDI YLNNSPLRKF VIYSLDMEPR IIRRLFRKSW
RPISKHVQGP AFFYGILKVG EPKDTFIKME GWTKGVVFVN GENLGRYWKK GPQETLYLPG
PWLHSGTNEI VVLEEQRAGQ EIKFLKYPYL GM
//
