ID H0XVK7_OTOGA Unreviewed; 383 AA.
AC H0XVK7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=WD repeat-containing protein 55 {ECO:0000256|ARBA:ARBA00021188, ECO:0000256|PIRNR:PIRNR038169};
GN Name=WDR55 {ECO:0000313|Ensembl:ENSOGAP00000020149.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000020149.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000020149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis.
CC Plays a central role during organogenesis.
CC {ECO:0000256|ARBA:ARBA00025196, ECO:0000256|PIRNR:PIRNR038169}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, nucleolus {ECO:0000256|PIRNR:PIRNR038169}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR55 family.
CC {ECO:0000256|ARBA:ARBA00007625, ECO:0000256|PIRNR:PIRNR038169}.
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DR EMBL; AAQR03009089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003782173.1; XM_003782125.2.
DR AlphaFoldDB; H0XVK7; -.
DR STRING; 30611.ENSOGAP00000020149; -.
DR Ensembl; ENSOGAT00000027563.1; ENSOGAP00000020149.1; ENSOGAG00000033796.1.
DR GeneID; 100951495; -.
DR KEGG; oga:100951495; -.
DR CTD; 54853; -.
DR eggNOG; KOG2444; Eukaryota.
DR GeneTree; ENSGT00940000153727; -.
DR HOGENOM; CLU_035848_0_1_1; -.
DR InParanoid; H0XVK7; -.
DR OMA; GIIKHWD; -.
DR OrthoDB; 153323at2759; -.
DR TreeFam; TF315175; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017422; WDR55.
DR PANTHER; PTHR44019; WD REPEAT-CONTAINING PROTEIN 55; 1.
DR PANTHER; PTHR44019:SF20; WD REPEAT-CONTAINING PROTEIN 55; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 2.
DR PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038169};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|PIRNR:PIRNR038169};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PIRNR:PIRNR038169}.
FT DOMAIN 45..122
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 298..332
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 42106 MW; B8928697C03A2F60 CRC64;
MDRVCEERST KDGSDEEDPD SAEAPARIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG
DVFVFSYSCQ EGETKELWSS GHHLKSCRAV AFSEDGQKLV TVSKDKAIHV LDVEQGRLEG
RISKAHGAPI NSLLLVDENI LATGDDTGCI RLWDQRKEGP LMDMRQHEEY IADMALDPAK
KLLLTASGDG CLGVFNIKRR RFELLSEPQS GDLTSVTLMK SGKKVTCGSS EGTIYLFNWN
GFGATSDRFA LRTESIDCMV PVTESLLCIG STDGIIRAVN ILPNRVVGSV GQHAGEPVEK
LALSHCGRFL ASSGHDQRLK FWDLTQLRTV VVNDYRRRKK KGGPLRALSS KAWSTDDFFV
GLREEGEDSV AWQEDEEESD DSD
//
