ID H0XX13_OTOGA Unreviewed; 367 AA.
AC H0XX13;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Tyrosyl-DNA phosphodiesterase 2 {ECO:0000256|ARBA:ARBA00017870};
DE AltName: Full=5'-tyrosyl-DNA phosphodiesterase {ECO:0000256|ARBA:ARBA00031304};
GN Name=TDP2 {ECO:0000313|Ensembl:ENSOGAP00000020656.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000020656.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000020656.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}.
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DR EMBL; AAQR03056096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XX13; -.
DR STRING; 30611.ENSOGAP00000020656; -.
DR Ensembl; ENSOGAT00000034876.1; ENSOGAP00000020656.1; ENSOGAG00000025303.1.
DR eggNOG; KOG2756; Eukaryota.
DR GeneTree; ENSGT00390000014242; -.
DR HOGENOM; CLU_047318_0_0_1; -.
DR InParanoid; H0XX13; -.
DR OMA; AENDWDM; -.
DR TreeFam; TF314813; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0070260; F:5'-tyrosyl-DNA phosphodiesterase activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0030145; F:manganese ion binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0036317; F:tyrosyl-RNA phosphodiesterase activity; IEA:Ensembl.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR CDD; cd09080; TDP2; 1.
DR CDD; cd14344; UBA_TYDP2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR15822; TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR15822:SF4; TYROSYL-DNA PHOSPHODIESTERASE 2; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF14555; UBA_4; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 122..356
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 41431 MW; 72AA733F93E65A01 CRC64;
EGWELMEEGK GPEGGARAAD ETDEPEVKKR RLLCAEFAAV ASCDAAVAQC YLAENDWEME
RALNSYFEPP VDESALESRP ETASEPENCV DLTNEEATES TSSKISPSAD TQQEDGSVFS
FITWNIDGLD LNNLPERARG VCSYLTLYTP DVVFLQEVIP PYYSYLKKRA SNYEIITGRE
EGYFTAIMLK KSKVKLKSHE VIPFPDTKMM RNLLCVRVSV SGSEFYLMTS HLESTKGHAK
ERMNQLKIVL KKMQEAPESA TVIFAGDTNL RDQEVTKYGG LPNNILDVWE FLGKPKHCQY
TWDTQMNSNL GITSTCKLRF DRIFFRTAGE ESHIIPRSLD LLGLEKLDCG RFPSDHWGLL
CNLDIIL
//
