ID   H0XZD0_OTOGA            Unreviewed;       836 AA.
AC   H0XZD0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Zinc finger CCCH-type containing 12B {ECO:0000313|Ensembl:ENSOGAP00000021473.1};
GN   Name=ZC3H12B {ECO:0000313|Ensembl:ENSOGAP00000021473.1};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021473.1, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000021473.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the ZC3H12 family.
CC       {ECO:0000256|ARBA:ARBA00010922}.
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DR   EMBL; AAQR03183771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03183772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003803205.1; XM_003803157.1.
DR   AlphaFoldDB; H0XZD0; -.
DR   STRING; 30611.ENSOGAP00000021473; -.
DR   Ensembl; ENSOGAT00000025725.1; ENSOGAP00000021473.1; ENSOGAG00000029439.1.
DR   GeneID; 100966749; -.
DR   KEGG; oga:100966749; -.
DR   CTD; 340554; -.
DR   eggNOG; KOG3777; Eukaryota.
DR   GeneTree; ENSGT00940000159316; -.
DR   HOGENOM; CLU_013020_1_0_1; -.
DR   InParanoid; H0XZD0; -.
DR   OMA; LEHMTSM; -.
DR   OrthoDB; 180910at2759; -.
DR   TreeFam; TF315783; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd18729; PIN_Zc3h12-like; 1.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   InterPro; IPR040546; Rege-1_UBA-like.
DR   InterPro; IPR040757; Regnase_1/ZC3H12_C.
DR   InterPro; IPR021869; RNase_Zc3h12_NYN.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR   PANTHER; PTHR12876:SF27; RIBONUCLEASE ZC3H12B-RELATED; 1.
DR   Pfam; PF18561; Regnase_1_C; 1.
DR   Pfam; PF11977; RNase_Zc3h12a; 1.
DR   Pfam; PF18039; UBA_6; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}.
FT   DOMAIN          355..380
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         355..380
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   836 AA;  94227 MW;  8622F806B924DBEA CRC64;
     MTATAAVETP KMEKSASKEE KQQPKQDSTE QGNADSEEWM SSDSDPEQII LKSSDKNKRS
     QPEDGQLKKK EMPSKPHRQL CRSPCLDRAS FSQSSILQDS KLDLEKEYQA KMEFALKLGY
     AEEQIQSVLN KLGPESLIND VLAELVRLGN KGDSEGQINL SLLVPRGPDS REIASPELSL
     EEDIDNSDNL RPVVIDGSNV AMSHGNKEEF SCRGIQLAVD WFLDKGHKDI TVFVPAWRKE
     QSRPDAPITD QDILRKLEKE KILVFTPSRR VQGRRVVCYD DRFIVKLAFD SDGIIVSNDN
     YRDLQVEKPE WKKFIEERLL MYSFVNDKFM PPDDPLGRHG PSLENFLRKR PVVPEHKKQP
     CPYGKKCTYG HKCKYYHPER ANQPQRSVAD ELRISAKLST VKTMSEGTLA KCGTGMSNAK
     GEITSEVKRV APKHQSDPSI RSVAVEPEEW LPIARKPEAS SVPSLVTALS VPTIPPSKSH
     AVGALNTRSA SSPVPGSSHF PHQKTSLEHL ASMQYPPILV TNSHGNPISY AEQYPKFESM
     GNHGYYSVLG DFSKLNINSM HNREYYMAEA DRGLYARNPN LCPDSRMSHT RNDNYSSYNN
     LYLAVADAHP ESSLKLHRSA SQNRLQPFPH GYHEALTRVQ SYGPEDSKQA PHKQSVSHLA
     LHAQHPPTGA RSSCPGDYPV PPSVHQGANS QPGRALVMTR MDSISDSRLY ENNPMRQRRP
     PLCREQHASW DPLPCATDSY GYHSYPLSNS LMQPCYEPVM VRSMPEKMEQ LWRNPWFGMC
     NDSREHMIPE HQYQTYKNLC NIFPSNIVLA VMEKNPHTAD AQQLAALIVA KLRAAR
//