ID H0XZG3_OTOGA Unreviewed; 162 AA.
AC H0XZG3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOGAP00000021506.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021506.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000021506.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004520}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}.
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DR EMBL; AAQR03169277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03169286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0XZG3; -.
DR STRING; 30611.ENSOGAP00000021506; -.
DR Ensembl; ENSOGAT00000028878.1; ENSOGAP00000021506.1; ENSOGAG00000031643.1.
DR eggNOG; KOG2736; Eukaryota.
DR GeneTree; ENSGT00940000158751; -.
DR HOGENOM; CLU_138903_0_0_1; -.
DR InParanoid; H0XZG3; -.
DR OMA; PHHEDTE; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR GO; GO:0042987; P:amyloid precursor protein catabolic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR InterPro; IPR002031; Pept_A22A_PS1.
DR InterPro; IPR001108; Peptidase_A22A.
DR PANTHER; PTHR10202; PRESENILIN; 1.
DR PANTHER; PTHR10202:SF18; PRESENILIN-1; 1.
DR Pfam; PF01080; Presenilin; 1.
DR PRINTS; PR01073; PRESENILIN1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 82..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 14..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 162 AA; 18388 MW; 64ACEF5BF03A5A43 CRC64;
MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DIRERQDHGD RRTLGNPEPL SNGRPQGNSP
PVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLYLSFPHH
EDTETVGQRA LHSILNAAIM ISVIVVMTIL LVVLYKYRCY KV
//
