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Database: UniProt
Entry: H0Y028_OTOGA
LinkDB: H0Y028_OTOGA
Original site: H0Y028_OTOGA 
ID   H0Y028_OTOGA            Unreviewed;       498 AA.
AC   H0Y028;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   10-APR-2019, entry version 34.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=LOC100955966 {ECO:0000313|Ensembl:ENSOGAP00000021721};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021721, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000021721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000021721}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; AAQR03068863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000021721; -.
DR   Ensembl; ENSOGAT00000030563; ENSOGAP00000021721; ENSOGAG00000033573.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   InParanoid; H0Y028; -.
DR   OMA; NVTIFYH; -.
DR   TreeFam; TF321598; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    498       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546538.
FT   TRANSMEM    452    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   ACT_SITE    132    132       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    354    354       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     44    337       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    208    224       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    362    373       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    367    422       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    424    433       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   498 AA;  57348 MW;  95C3C9EBDB7DBCAB CRC64;
     LCLAWLGELP LFILLTQADL KPAMPPVINN QPFNIFWAAP TVYCKNFYNV DMNLQVFDII
     SNPLETQSGS TIAIFYPNEL GYYPFFSQEG KSFNGGIPQN MSLSKHLRKA ADDIGEALPW
     WRSAGLVVID WESWKPQWDR NWGSRVIYKS HSLAFTRSHH PDWSEMKVKT VAQEEFENAG
     RSLMNITLTL ALEMRPKCLW GFYLYPDCYN YDYRINPEMY TGNCPDGEIF RNNQLMWLWR
     KSTALYPSIY LDKILKSSLN ALKFVHYRVR EAMRIAEMAR PDYVLPVFIF SRPFYLQSIE
     VLSQEDLVHT IGESASLGAA GIILWGGYNY SASKENCLSV KKSIQGPLGH YAVNVTSAAK
     LCSHSLCNNR GRCVRKTPES SFYLHMPGNS GKKYVENKSF RFVISENSKV KTITHMKNGF
     VCHCYYGWHG QSCHYHTSDL MRGKNKAPRA NLNLLAFLSL VLPVILLKFC YPLKYWNKNV
     DFFLFNCKPL LKYVLALK
//
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