ID H0Y0F9_OTOGA Unreviewed; 1282 AA.
AC H0Y0F9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=NRK {ECO:0000313|Ensembl:ENSOGAP00000021852.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021852.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000021852.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03173986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOGAT00000025401.1; ENSOGAP00000021852.1; ENSOGAG00000000977.2.
DR GeneTree; ENSGT00940000161533; -.
DR HOGENOM; CLU_001831_0_0_1; -.
DR OMA; AIKVICI; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47096; MISSHAPEN LIKE KINASE 1; 1.
DR PANTHER; PTHR47096:SF2; NIK-RELATED PROTEIN KINASE; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 1..232
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 959..1256
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 401..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..491
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1282 AA; 145801 MW; DE1AB180B0D78DD4 CRC64;
LTQDEEEDLR TELNLLRKYS FHKNIVSFYG AFFKLSPPGQ RHQLWMVMEL CAAGSVTDVV
RMTRNQSLKE DWIAYICREI LQGLAHLHAH RVIHRDIKGQ NVLLTHNAEV KLVDFGVSAQ
VSRTNGRRNS FIGTPYWMAP EVIDCDEDPR RSYDYRSDVW SVGITAIEMA EGAPPLCNLQ
PLEALFVILR ESAPTVKSSG WSRKFHNFME QCMIKNFLIR PTSANMLHHP FVQNIKHERH
VVESLTKHLT GIIKKRQKKV TTGKYNKKIL SGNVEENFLL PPNDSLIPGH RTINHELLKL
PTSSRCRPLR VLHGEPSQQL QGAARVLMPL QAVDNTPRLL QGQAQAPQRL QGAARVFMPL
QAQVKAKTSR PLQMHLKAPP RLRKVAGVFM PLQAQGKIPR PLRAQAQAQV PKEQQAQAQD
QPSEQPQDLD QVPEEFQGQG QVPEQRQGQG QAPGQQQRQN QVPEQNLEPE QPEVQEEASE
TEPEAEEEEP ESLQVQALVF LPLLSQNHHV LLPLHLDTQV LIPVEEQTEG LSLAQAWVLE
PSQAVSSVQA LIEGLSRDLL RAPNSDELRP LGPLQTLLEN LSSNVFYSQP EQARKKKSRV
SSLRQALAKR LSPKNGHVLI PMLGHKAKEQ KNKPGPNKTE TFLNVSFKKT KKVFAKSSEW
PSSNRIQEGR ISRRDESKVL GRSNRIRSRK SRKWFGNWVV RHSIESSSEE ESPVPRRRSQ
SSPPYSTIDQ NLLIDIHERK IKEFRPLKKI SRHSGTYREV YRSYKRSYKS YSRHYGGSAA
SGASMATGDQ EGYEANIGSG RNSRDNAGQG VSGTNENDGA LELSGRENRS GRRGPRLERL
VSLDFEHQQE VGTKEYELLS WHTRIMKNGS RVGFKQSPNK RKTGFYPLLG TRPCAASPAP
DDESDNRFFR CLLFSFHRFQ EELLKYQIKC KYNEVNVNPL CASSAYKKPL IHMYEKEFTS
EICCGSLWGT GVNLLLGTRS NLYLMDRSGK AEITKLIKRR PFRQIQVVES LNLLITISGR
KNRLRVYHLT WLRNKILNND PGSKRRQEEM LKTEDACKAI DKLTGCEHFS VLQHEETTYI
AVALKSSIHL YAWAPKSFDE STAIKVFPTL GHKPVTVDLA IGSEKRLKIF FSSSTGYHSI
DAESEVMSDV TLPNNVRYHV TRHNIIILPD GLGIGMMLTF NAEALSAEEN EQLFKKILDV
WKDIPSSIAL ECSQRTTGWG QMAIEARSLQ PRVLESELKR RSIKKLRFLC SRGDKVFFTS
ILRNRHSRVY FMTLGELEEL QS
//
