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Database: UniProt
Entry: H0Y0T8_OTOGA
LinkDB: H0Y0T8_OTOGA
Original site: H0Y0T8_OTOGA 
ID   H0Y0T8_OTOGA            Unreviewed;       329 AA.
AC   H0Y0T8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   10-APR-2019, entry version 37.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL3 {ECO:0000313|Ensembl:ENSOGAP00000021981};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000021981, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000021981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000021981}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; AAQR03164212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000021981; -.
DR   Ensembl; ENSOGAT00000027539; ENSOGAP00000021981; ENSOGAG00000028507.
DR   eggNOG; ENOG410IH0U; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   InParanoid; H0Y0T8; -.
DR   OMA; FPACGNG; -.
DR   TreeFam; TF321598; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0002080; C:acrosomal membrane; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR   GO; GO:0033906; F:hyaluronoglucuronidase activity; IEA:Ensembl.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR   GO; GO:0030214; P:hyaluronan catabolic process; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:2000355; P:negative regulation of ovarian follicle development; IEA:Ensembl.
DR   GO; GO:0001552; P:ovarian follicle atresia; IEA:Ensembl.
DR   GO; GO:0007341; P:penetration of zona pellucida; IEA:Ensembl.
DR   GO; GO:2000368; P:positive regulation of acrosomal vesicle exocytosis; IEA:Ensembl.
DR   GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   InterPro; IPR027260; Hyaluronidase-3.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   PANTHER; PTHR11769:SF19; PTHR11769:SF19; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    329       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003545668.
FT   ACT_SITE    127    127       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   DISULFID    203    218       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   329 AA;  36723 MW;  09EC513E3CEEADCF CRC64;
     MTMQLGPALV LGVAPCLGYG QPLLQAPEHP FSVLWNVSQA HTHFGVHLPL SALGIIGNHG
     QHFYGQNITI FYKNHLGLYP YLGPRNTAHN GGIPQAVPFD HHLTQATNQI HCSLQPSFAG
     LAVLDWEEWY PLWTGNWGHH RAYQAASWTW AQRMFPNLDP QEQLHKAHIG FEQAAHALME
     ETLWLGQALQ PHGLWGFYCY PACGNGWHSM ASNYTGHCHG ATLARNTELH WLWAASSALF
     PSIYLPPKLP PTTTRFVQHR LEETFRVALA GHPHPLPVLA YARLTHQSSG RFLSQDDLVW
     TIDVSAALGA TGMVLWGDLS FSSSEKECW
//
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