ID H0Y1B1_OTOGA Unreviewed; 1522 AA.
AC H0Y1B1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=GLI family zinc finger 2 {ECO:0000313|Ensembl:ENSOGAP00000022154.1};
GN Name=GLI2 {ECO:0000313|Ensembl:ENSOGAP00000022154.1};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000022154.1, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000022154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00010831}.
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DR EMBL; AAQR03093648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03093657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000022154; -.
DR Ensembl; ENSOGAT00000024074.1; ENSOGAP00000022154.1; ENSOGAG00000032438.1.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159213; -.
DR HOGENOM; CLU_003666_2_0_1; -.
DR InParanoid; H0Y1B1; -.
DR OMA; PPESTCF; -.
DR TreeFam; TF350216; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0097542; C:ciliary tip; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0021696; P:cerebellar cortex morphogenesis; IEA:Ensembl.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0021508; P:floor plate formation; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0007442; P:hindgut morphogenesis; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0060603; P:mammary gland duct morphogenesis; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0060032; P:notochord regression; IEA:Ensembl.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
DR GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
DR GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
DR GO; GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Ensembl.
DR GO; GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IEA:Ensembl.
DR GO; GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IEA:Ensembl.
DR GO; GO:0021965; P:spinal cord ventral commissure morphogenesis; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR043359; GLI-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45718; TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS; 1.
DR PANTHER; PTHR45718:SF6; ZINC FINGER PROTEIN GLI2; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 370..402
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 408..435
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 436..465
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 466..496
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 497..527
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 293..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1522 AA; 162451 MW; E81ADA7888FD7849 CRC64;
PQHLLPPFHA PFPIDMRHQE GRYHYEPHSV HGVHGPPTLS GSPVISDISL IRLSPHPAGP
GDPPFNAPHP YVNPHMEHYL RSVHSSPTLS MISAARGLSP ADVAQEHLKD RGLFGLPAPG
TNPSDYYHQM TLMAGHPAPY GDLLMQSGGA ASTPHLHDYL NPVDVSRFSS PRVTPRLSRK
RALSISPLSD ASLDLQRMIR TSPNSLVAYI NNSRSSSAAS GSYGHLSAGA LSPAFTFPHP
INPVAYQQIL SQQRGLGSAF GHTPPLLQPS PTFLAQQPMA LASISAAPSQ LSSSSNCLGD
ANQNKQSSES AVSSTVNPIT IHKRSKVKTE AEGLRPASPL ALTQEQLADL KEDLDRDDCK
QEAEVVIYET NCHWEDCTKE FDTQEQLVHH INNEHIHGEK KEFVCRWQAC TREQKPFKAQ
YMLVVHMRRH TGEKPHKCTF EGCSKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA
SDRAKHQNRT HSNEKPYICK IPGCTKRYTD PSSLRKHVKT VHGPDAHVTK KQRNDVHLRT
PLLKEIGESE ASTEPGGRAS EDSAEASSTI QAVEDCLHIK AIKTESSGLC QSSPGAQSSC
SSEPSPLGSA PNNDSGVEMP GTGPGSLGDL TALDDTPPGA NASALATPST GGLQLRKHMT
TMHRFEQLKK EKLKSLKDSC SWAGPAPHTR NTKLPPLPGN GSMLENFSGN GGGGPAGLLP
NPRLSELSAS EVTMLSQLQE RRDSSTSTVS SAYTVSRRSS GISPYFSSRR SSEASPLGAG
RPHNASSADS YDPISTDASR RSSEASQCSG GPGLLNLTPA QQYSLRAKYA AATGGPPPTP
LPGLERMSLR TRLALLDAPE RALPAACPRP LGPRRGSDGP TYGHGHSQMG AAPAFPHEAL
GSGARRASDP VRRPDALALP RVQRFHSAHN VNPGLLPPCA ERRGLRLQSH SSADSSLAHS
AYSPRPPSIS ENVVMEAMAA GTDSVGPDAD LELQEDDLVL PDDVVQYIKA HASGSQDESS
GQVYATEGTS FSDNPKLPSP GLHSQRRMVA ADSDLGPSAP VLGGCQLGYG TPSSLNKDNM
PVQWNEVSSG TMDALASQAK QPPFPQGNLA TVQQKPAFGQ YPGYSPQGLQ ESPGGLDSTQ
PHLRPRSNTS STPRVNYMQQ LRQPATGGQC ANMTTVMSPQ TGYGQAHSQL SPSTVSGALN
QFPLSCSNMT AKPGHLGHPQ HAEVAPDTIM MGSRLRELGV PNSTLAGGPP PHPVQSYPQQ
SHHLAAPMSQ EGYRQGPGLL PSHQPGFMEP QPGTMGVSAA SFGLVQPRPP LEPNPAGRHH
GVRAGQQQLA YARATGHAMA AVPANQETAE AVPKGVMGNM VSLPPQPPPQ DMGGAQDHSM
LYYYGQIHMY EQDEGLENLG GCQVTRSQPL QPQACPDSIQ PQPLPSPGVN QVSSTVDSQL
LEAPQIDFDA IMDDGDHSSL FSGTLSPSLL HSLSQSSSRL TTPRNPLTLP SIPTGISNMA
VGDMSSMLTS LAEESKFLNM MT
//
