ID H0Y337_HUMAN Unreviewed; 975 AA.
AC H0Y337;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Utrophin {ECO:0000313|Ensembl:ENSP00000356494.4};
GN Name=UTRN {ECO:0000313|Ensembl:ENSP00000356494.4};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356494.4, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000356494.4, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0007829|PubMed:18220336}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [3] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5] {ECO:0007829|PubMed:25944712}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [6] {ECO:0000313|Ensembl:ENSP00000356494.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL024474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL357149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL513184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL513475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; H0Y337; -.
DR IntAct; H0Y337; 1.
DR iPTMnet; H0Y337; -.
DR MassIVE; H0Y337; -.
DR MaxQB; H0Y337; -.
DR PeptideAtlas; H0Y337; -.
DR ProteomicsDB; 34431; -.
DR Antibodypedia; 4282; 110 antibodies from 20 providers.
DR Ensembl; ENST00000367524.8; ENSP00000356494.4; ENSG00000152818.20.
DR UCSC; uc063sao.1; human.
DR HGNC; HGNC:12635; UTRN.
DR VEuPathDB; HostDB:ENSG00000152818; -.
DR GeneTree; ENSGT00940000153467; -.
DR HOGENOM; CLU_081409_1_0_1; -.
DR ChiTaRS; UTRN; human.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000152818; Expressed in calcaneal tendon and 194 other cell types or tissues.
DR ExpressionAtlas; H0Y337; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16247; EFh_UTRO; 1.
DR CDD; cd00176; SPEC; 2.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 3.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR PANTHER; PTHR12268:SF26; UTROPHIN; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 2.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00150; SPEC; 3.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:H0Y337,
KW ECO:0007829|MaxQB:H0Y337};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 367..400
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 620..676
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 915..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 241..268
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 795..829
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 867..901
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 975 AA; 111770 MW; 54A953FD6BABCFDF CRC64;
MQILRCLQKC GKLKMMAVVR TSLQKVVVLL HRLQRMAVSS PRYQKLCKDI QAEIDAHNDI
FKSIDGNRQK MVKALGNSEE ATMLQHRLDD MNQRWNDLKA KSASIRAHLE ASAEKWNRLL
MSLEELIKWL NMKDEELKKQ MPIGGDVPAL QLQYDHCKAL RRELKEKEYS VLNAVDQARV
FLADQPIEAP EEPRRNLQSK TELTPEERAQ KIAKAMRKQS SEVKEKWESL NAVTSNWQKQ
VDKALEKLRD LQGAMDDLDA DMKEAESVRN GWKPVGDLLI DSLQDHIEKI MAFREEIAPI
NFKVKTVNDL SSQLSPLDLH PSLKMSRQLD DLNMRWKLLQ VSVDDRLKQL QEAHRDFGPS
SQHFLSTSVQ LPWQRSISHN KVPYYINHQT QTTCWDHPKM TELFQSLADL NNVRFSAYRT
AIKIRRLQKA LCLDLLELST TNEIFKQHKL NQNDQLLSVP DVINCLTTTY DGLEQMHKDL
VNVPLCVDMC LNWLLNVYDT GRTGKIRVQS LKIGLMSLSK GLLEEKYRYL FKEVAGPTEM
CDQRQLGLLL HDAIQIPRQL GEVAAFGGSN IEPSVRSCFQ QNNNKPEISV KEFIDWMHLE
PQSMVWLPVL HRVAAAETAK HQAKCNICKE CPIVGFRYRS LKHFNYDVCQ SCFFSGRTAK
GHKLHYPMVE YCIPTTSGED VRDFTKVLKN KFRSKKYFAK HPRLGYLPVQ TVLEGDNLET
PSQSPQLFHD DTHSRIEQYA TRLAQMERTN GSFLTDSSST TGSVEDEHAL IQQYCQTLGG
ESPVSQPQSP AQILKSVERE ERGELERIIA DLEEEQRNLQ VEYEQLKDQH LRRGLPVGSP
PESIISPHHT SEDSELIAEA KLLRQHKGRL EARMQILEDH NKQLESQLHR LRQLLEQPES
DSRINGVSPW ASPQHSALSY SLDPDASGPQ FHQAAGEDLL APPHDTSTDL TEVMEQIHST
FPSCCPNVPS RPQAM
//
