ID H0Y7N4_HUMAN Unreviewed; 1090 AA.
AC H0Y7N4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Dedicator of cytokinesis 5 {ECO:0000313|Ensembl:ENSP00000414125.1};
DE Flags: Fragment;
GN Name=DOCK5 {ECO:0000313|Ensembl:ENSP00000414125.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000414125.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000414125.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0007829|PubMed:18691976}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [3] {ECO:0007829|PubMed:19608861}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [4] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6] {ECO:0000313|Ensembl:ENSP00000414125.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; AC041005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC091185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF510313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0Y7N4; -.
DR MaxQB; H0Y7N4; -.
DR PeptideAtlas; H0Y7N4; -.
DR ProteomicsDB; 35478; -.
DR Antibodypedia; 2898; 107 antibodies from 16 providers.
DR Ensembl; ENST00000444569.5; ENSP00000414125.1; ENSG00000147459.18.
DR UCSC; uc064lhi.1; human.
DR HGNC; HGNC:23476; DOCK5.
DR VEuPathDB; HostDB:ENSG00000147459; -.
DR GeneTree; ENSGT00940000157734; -.
DR HOGENOM; CLU_000595_1_1_1; -.
DR ChiTaRS; DOCK5; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000147459; Expressed in ileal mucosa and 181 other cell types or tissues.
DR ExpressionAtlas; H0Y7N4; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF3; DEDICATOR OF CYTOKINESIS PROTEIN 5; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:H0Y7N4,
KW ECO:0007829|MaxQB:H0Y7N4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 215..399
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1003..1090
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000414125.1"
SQ SEQUENCE 1090 AA; 126126 MW; 86C4BE7E30034B15 CRC64;
XVNPAEPRFA GPVHLQYHPH LWPLCELQEL CLQHRGRCRV VYGPLRPRPV HFYQDLSSMD
LIRPRVSLVC QIVRVGHMEL KEGKKHTCGL RRPFGVAVMD ITDIIHGKVD DEEKQHFIPF
QQIAMETYIR QRQLIMSPLI TSHVIGENEP LTSVLNKVIA AKEVNHKGQG LWVSLKLLPG
DLTQVQKNFS HLVDRSTAIA RKMGFPEIIL PGDVRNDIYV TLIHGEFDKG KKKTPKNVEV
TMSVHDEEGK LLEKAIHPGA GYEGISEYKS VVYYQVKQPC WYETVKVSIA IEEVTRCHIR
FTFRHRSSQE TRDKSERAFG VAFVKLMNPD GTTLQDGRHD LVVYKGDNKK MEDAKFYLTL
PGTKMEMEEK ELQASKNLVT FTPSKDSTKD SFQIATLICS TKLTQNVDLL GLLNWRSNSQ
NIKHNLKKLM EVDGGEIVKF LQDTLDALFN IMMEMSDSET YDFLVFDALV FIISLIGDIK
FQHFNPVLET YIYKHFSATL AYVKLSKVLN FYVANADDSS KTELLFAALK ALKYLFRFII
QSRVLYLRFY GQSKDGDEFN NSIRQLFLAF NMLMDRPLEE AVKIKGAALK YLPSIINDVK
LVFDPVELSV LFCKFIQSIP DNQLVRQKLN CMTKIVESTL FRQSECREVL LPLLTDQLSG
QLDDNSNKPD HEASSQLLSN ILEVLDRKDV GATAVHIQLI MERLLRRINR TVIGMNRQSP
HIGSFVACMI ALLQQMDDSH YSHYISTFKT RQDIIDFLME TFIMFKDLIG KNVYAKDWMV
MNMTQNRVFL RAINQFAEVL TRFFMDQASF ELQLWNNYFH LAVAFLTHES LQLETFSQAK
RNKIVKKYGD MRKEIGFRIR DMWYNLGPHK IKFIPSMVGP ILEVTLTPEV ELRKATIPIF
FDMMQCEFNF SGNGNFHMFE NELITKLDQE VEGGRGDEQY KVLLEKLLLE HCRKHKYLSS
SGEVFALLVS SLLENLLDYR TIIMQDESKE NRMSCTVNVL NFYKEKKRED IYIRYLYKLR
DLHRDCENYT EAAYTLLLHA ELLQVNGSES LFQQGGVQCP FRLNSIHFMI LMGKNFIPGI
SFYTSFFSSF
//
