ID H0Y7R9_HUMAN Unreviewed; 772 AA.
AC H0Y7R9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Cadherin EGF LAG seven-pass G-type receptor 1 {ECO:0000313|Ensembl:ENSP00000414689};
GN Name=CELSR1 {ECO:0000313|Ensembl:ENSP00000414689};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000414689, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000414689, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2] {ECO:0000313|Ensembl:ENSP00000414689}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2012) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AL021392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL031588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL031597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF457493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR IntAct; H0Y7R9; 1.
DR MassIVE; H0Y7R9; -.
DR MaxQB; H0Y7R9; -.
DR PeptideAtlas; H0Y7R9; -.
DR ProteomicsDB; 35502; -.
DR Antibodypedia; 13897; 229 antibodies from 30 providers.
DR Ensembl; ENST00000454637; ENSP00000414689; ENSG00000075275.
DR UCSC; uc062ffx.1; human.
DR HGNC; HGNC:1850; CELSR1.
DR OpenTargets; ENSG00000075275; -.
DR VEuPathDB; HostDB:ENSG00000075275; -.
DR HOGENOM; CLU_378956_0_0_1; -.
DR ChiTaRS; CELSR1; human.
DR Proteomes; UP000005640; Chromosome 22.
DR Bgee; ENSG00000075275; Expressed in ventricular zone and 147 other cell types or tissues.
DR ExpressionAtlas; H0Y7R9; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR24026:SF36; CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 1; 1.
DR PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SMART; SM00181; EGF; 2.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|EPD:H0Y7R9,
KW ECO:0007829|MaxQB:H0Y7R9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5..62
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 63..164
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 165..267
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 268..374
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 375..476
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 502..599
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 678..736
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 738..771
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 726..735
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 772 AA; 85496 MW; C30F76B0215921CB CRC64;
XDFPFQIHNS SGWITVCAEL DREEVEHYSF GVEAVDHGSP PMSSSTSVSI TVLDVNDNDP
VFTQPTYELR LNEDAAVGSS VLTLQARDRD ANSVITYQLT GGNTRNRFAL SSQRGGGLIT
LALPLDYKQE QQYVLAVTAS DGTRSHTAHV LINVTDANTH RPVFQSSHYT VSVSEDRPVG
TSIATLSAND EDTGENARIT YVIQDPVPQF RIDPDSGTMY TMMELDYENQ VAYTLTIMAQ
DNGIPQKSDT TTLEILILDA NDNAPQFLWD FYQGSIFEDA PPSTSILQVS ATDRDSGPNG
RLLYTFQGGD DGDGDFYIEP TSGVIRTQRR LDRENVAVYN LWALAVDRGS PTPLSASVEI
QVTILDINDN APMFEKDELE LFVEENNPVG SVVAKIRAND PDEGPNAQIM YQIVEGDMRH
FFQLDLLNGD LRAMVELDFE VRREYVLVVQ ATSAPLVSRA TVHILLVDQN DNPPVLPDFQ
ILFNNYVTNK SNSFPTGVIG CIPAHDPDVS DSLNYTFVQG NELRLLLLDP ATGELQLSRD
LDNNRPLEAL MEVSVSDGIH SVTAFCTLRV TIITDDMLTN SITVRLENMS QEKFLSPLLA
LFVEGVAAVL STTKDDVFVF NVQNDTDVSS NILNVTFSAL LPGGVRGQFF PSEDLQEQIY
LNRTLLTTIS TQRVLPFDDN ICLREPCENY MKCVSVLRFD SSAPFLSSTT VLFRPIHPIN
GLRCRCPPGF TGDYCETEID LCYSDPCGAN GRCRSREGGY TCECFEDFTE IS
//
