ID H0YBB2_HUMAN Unreviewed; 336 AA.
AC H0YBB2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Collagen type XIV alpha 1 chain {ECO:0000313|Ensembl:ENSP00000429123.1};
DE Flags: Fragment;
GN Name=COL14A1 {ECO:0000313|Ensembl:ENSP00000429123.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429123.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000429123.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000429123.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC020603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC091563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0YBB2; -.
DR PeptideAtlas; H0YBB2; -.
DR ProteomicsDB; 36663; -.
DR Antibodypedia; 13712; 131 antibodies from 24 providers.
DR Ensembl; ENST00000523142.5; ENSP00000429123.1; ENSG00000187955.13.
DR UCSC; uc064pur.1; human.
DR HGNC; HGNC:2191; COL14A1.
DR VEuPathDB; HostDB:ENSG00000187955; -.
DR GeneTree; ENSGT00940000153769; -.
DR ChiTaRS; COL14A1; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000187955; Expressed in descending thoracic aorta and 169 other cell types or tissues.
DR ExpressionAtlas; H0YBB2; baseline and differential.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF15; COLLAGEN ALPHA-1(XIV) CHAIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H0YBB2,
KW ECO:0007829|MaxQB:H0YBB2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 10..51
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 112..201
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 202..295
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000429123.1"
FT NON_TER 336
FT /evidence="ECO:0000313|Ensembl:ENSP00000429123.1"
SQ SEQUENCE 336 AA; 36953 MW; D5E61CF45700BA83 CRC64;
XVCQTPAIAD IVILVDGSWS IGRFNFRLVR HFLENLVTAF DVGSEKTRIG VKNADVNELQ
EIASEPDSTH VYNVAEFDLM HTVVESLTRT LCSRVEEQDR EIKASAHAIT GPPTELITSE
VTARSFMVNW THAPGNVEKY RVVYYPTRGG KPDEVVVDGT VSSTVLKNLM SLTEYQIAVF
AIYAHTASEG LRGTETTLAL PMASDLLLYD VTENSMRVKW DAVPGASGYL ILYAPLTEGL
AGDEKEMKIG ETHTDIELSG LLPNTEYTVT VYAMFGEEAS DPVTGQETTL ALSPPRNLRI
SNVGSNSARL TWDPTSRQIN GYRIVYNNAD GTEINE
//
