ID H0YDN3_HUMAN Unreviewed; 171 AA.
AC H0YDN3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 2 {ECO:0000313|Ensembl:ENSP00000434000.1};
DE Flags: Fragment;
GN Name=SCUBE2 {ECO:0000313|Ensembl:ENSP00000434000.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434000.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000434000.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000434000.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AC079296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0YDN3; -.
DR PeptideAtlas; H0YDN3; -.
DR ProteomicsDB; 37452; -.
DR Antibodypedia; 1601; 197 antibodies from 27 providers.
DR Ensembl; ENST00000531429.1; ENSP00000434000.1; ENSG00000175356.14.
DR UCSC; uc057ywg.1; human.
DR HGNC; HGNC:30425; SCUBE2.
DR VEuPathDB; HostDB:ENSG00000175356; -.
DR GeneTree; ENSGT00940000153185; -.
DR ChiTaRS; SCUBE2; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000175356; Expressed in corpus epididymis and 133 other cell types or tissues.
DR ExpressionAtlas; H0YDN3; baseline and differential.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Proteomics identification {ECO:0007829|PeptideAtlas:H0YDN3,
KW ECO:0007829|ProteomicsDB:H0YDN3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 129..167
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 133..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000434000.1"
FT NON_TER 171
FT /evidence="ECO:0000313|Ensembl:ENSP00000434000.1"
SQ SEQUENCE 171 AA; 18774 MW; 9F5E80C86C9F1202 CRC64;
XCSCHPQYKM HTDGRSCLER EDTVLEVTES NTTSVVDGDK RVKRRLLMET CAVNNGGCDR
TCKDTSTGVH CSCPVGFTLQ LDGKTCKDID ECQTRNGGCD HFCKNIVGSF DCGCKKGFKL
LTDEKSCQDV DECSLDRTCD HSCINHPGTF ACACNRGYTL YGFTHCGEVK G
//
