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Database: UniProt
Entry: H0YDX6_HUMAN
LinkDB: H0YDX6_HUMAN
Original site: H0YDX6_HUMAN 
ID   H0YDX6_HUMAN            Unreviewed;       183 AA.
AC   H0YDX6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=CD44 antigen {ECO:0000256|ARBA:ARBA00020474};
DE   AltName: Full=Extracellular matrix receptor III {ECO:0000256|ARBA:ARBA00033395};
DE   AltName: Full=GP90 lymphocyte homing/adhesion receptor {ECO:0000256|ARBA:ARBA00032514};
DE   AltName: Full=HUTCH-I {ECO:0000256|ARBA:ARBA00031823};
DE   AltName: Full=Hermes antigen {ECO:0000256|ARBA:ARBA00032917};
DE   AltName: Full=Hyaluronate receptor {ECO:0000256|ARBA:ARBA00031179};
DE   AltName: Full=Phagocytic glycoprotein 1 {ECO:0000256|ARBA:ARBA00029917};
DE   AltName: Full=Phagocytic glycoprotein I {ECO:0000256|ARBA:ARBA00029928};
DE   Flags: Fragment;
GN   Name=CD44 {ECO:0000313|Ensembl:ENSP00000434530.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434530.2, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434530.2, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0007829|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [3] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [5] {ECO:0007829|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [6] {ECO:0000313|Ensembl:ENSP00000434530.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR   EMBL; AL133330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL356215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SwissPalm; H0YDX6; -.
DR   MassIVE; H0YDX6; -.
DR   PeptideAtlas; H0YDX6; -.
DR   ProteomicsDB; 37545; -.
DR   Antibodypedia; 804; 6014 antibodies from 59 providers.
DR   Ensembl; ENST00000527889.6; ENSP00000434530.2; ENSG00000026508.21.
DR   UCSC; uc058ais.1; human.
DR   HGNC; HGNC:1681; CD44.
DR   VEuPathDB; HostDB:ENSG00000026508; -.
DR   GeneTree; ENSGT00530000063822; -.
DR   HOGENOM; CLU_1499605_0_0_1; -.
DR   ChiTaRS; CD44; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000026508; Expressed in parotid gland and 201 other cell types or tissues.
DR   ExpressionAtlas; H0YDX6; baseline and differential.
DR   GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd03516; Link_domain_CD44_like; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR001231; CD44_antigen.
DR   InterPro; IPR043210; CD44_antigen-like.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR000538; Link_dom.
DR   PANTHER; PTHR10225:SF6; CD44 ANTIGEN; 1.
DR   PANTHER; PTHR10225; HYALURONAN RECEPTOR; 1.
DR   Pfam; PF00193; Xlink; 1.
DR   PRINTS; PR00658; CD44.
DR   PRINTS; PR01265; LINKMODULE.
DR   SMART; SM00445; LINK; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   PROSITE; PS01241; LINK_1; 1.
DR   PROSITE; PS50963; LINK_2; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Proteomics identification {ECO:0007829|EPD:H0YDX6,
KW   ECO:0007829|MaxQB:H0YDX6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          1..76
FT                   /note="Link"
FT                   /evidence="ECO:0000259|PROSITE:PS50963"
FT   REGION          112..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..167
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000434530.2"
FT   NON_TER         183
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000434530.2"
SQ   SEQUENCE   183 AA;  19828 MW;  046BCE47209D4B2E CRC64;
     XRTEAADLCK AFNSTLPTMA QMEKALSIGF ETCRYGFIEG HVVIPRIHPN SICAANNTGV
     YILTSNTSQY DTYCFNASAP PEEDCTSVTD LPNAFDGPIT ITIVNRDGTR YVQKGEYRTN
     PEDIYPSNPT DDDVSSGSSS ERSSTSGDMD SSHSITLQPT ANPNTGLVED LDRTGPLSMT
     TQQ
//
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