ID H0YEM4_HUMAN Unreviewed; 723 AA.
AC H0YEM4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=von Willebrand factor A domain containing 3B {ECO:0000313|Ensembl:ENSP00000436153.1};
DE Flags: Fragment;
GN Name=VWA3B {ECO:0000313|Ensembl:ENSP00000436153.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436153.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000436153.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000436153.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC018691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0YEM4; -.
DR MaxQB; H0YEM4; -.
DR PeptideAtlas; H0YEM4; -.
DR ProteomicsDB; 37781; -.
DR Antibodypedia; 52631; 91 antibodies from 17 providers.
DR Ensembl; ENST00000473149.5; ENSP00000436153.1; ENSG00000168658.20.
DR UCSC; uc061mdk.1; human.
DR HGNC; HGNC:28385; VWA3B.
DR VEuPathDB; HostDB:ENSG00000168658; -.
DR GeneTree; ENSGT00940000157237; -.
DR HOGENOM; CLU_008285_1_1_1; -.
DR ChiTaRS; VWA3B; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000168658; Expressed in bronchial epithelial cell and 122 other cell types or tissues.
DR ExpressionAtlas; H0YEM4; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR032770; DUF4537.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46785; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B; 1.
DR PANTHER; PTHR46785:SF1; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B; 1.
DR Pfam; PF15057; DUF4537; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:H0YEM4,
KW ECO:0007829|ProteomicsDB:H0YEM4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..95
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 144..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000436153.1"
SQ SEQUENCE 723 AA; 81179 MW; AB8FBAD4A1F5AE0F CRC64;
XKTAFADKET QAIYLLTDGR PDQPPETVID QVKRFQEIPI YTISFNYNDE IANRFLKEVA
ALTGGEFHFY NFGCKDPTPP EAVQNEDLTL LVKEMEQGHS DLEKMQDLYS ESLIMDWWYN
AEKDGDSKHQ KEICSMISTP EKCAKPQSDV DSTQTSSLNM LKGPWGLSDQ KVQKKKVLHA
ESTKTSLLRS QMSSLRSSAC SERKDGLSNA SSRRTALSDK EMSILLAEEW LDDKSSEKVT
REGSQVYDHD SSDVSSENWL KTYGLVAKKL TLMDALSVAA VPHSSTYVPV LDKHVVSKVF
DEVFPLAHVC NDTNKMTLIN PQGAKLNIYK RKVEQAIQSY EKRLNKIVWR ALSQEEKEKL
DANKPIQYLE NKTVLNQALE RLNWPISLKE LSMLESEILA GKMYIQQAME LQEAAKKNYA
NKAPGEQQKL QGNPTKKTKS KRPDPLKGQK VIARCDENGF YFPGVVKKCV SRTQALVGFS
YGDTKVVSTS FITPVGGAMP CPLLQVGDYV FAKIVIPKGF DFYVPAIVIA LPNKHVATEK
FYTVLKCNNR REFCPRSALI KISQNKYALS CSHIKSPPIP EDPEVEDVEA RNSAFLFWPL
KEADTQDSRE PRREKPRRKK RPAKQPLQQA APSDSDGSSH GISSHGSCQG THPEPRVWVM
GGEHNIAYLR NTLKSLSRIV HLTSSFRFWA CLGSSAAKTL TSLSNAELCF PRQPTSTSPR
PGV
//
