ID H0YKA8_HUMAN Unreviewed; 199 AA.
AC H0YKA8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Src homology 2 domain containing F {ECO:0000313|Ensembl:ENSP00000452726.1};
DE Flags: Fragment;
GN Name=SHF {ECO:0000313|Ensembl:ENSP00000452726.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452726.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000452726.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000452726.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC051619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0YKA8; -.
DR PeptideAtlas; H0YKA8; -.
DR ProteomicsDB; 39602; -.
DR Antibodypedia; 42470; 118 antibodies from 20 providers.
DR Ensembl; ENST00000559566.5; ENSP00000452726.1; ENSG00000138606.20.
DR UCSC; uc059isz.1; human.
DR HGNC; HGNC:25116; SHF.
DR VEuPathDB; HostDB:ENSG00000138606; -.
DR GeneTree; ENSGT00940000159452; -.
DR HOGENOM; CLU_029444_2_1_1; -.
DR ChiTaRS; SHF; human.
DR Proteomes; UP000005640; Chromosome 15.
DR Bgee; ENSG00000138606; Expressed in cerebellar hemisphere and 113 other cell types or tissues.
DR ExpressionAtlas; H0YKA8; baseline and differential.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR15127; HEAVYWEIGHT, ISOFORM A; 1.
DR PANTHER; PTHR15127:SF28; SH2 DOMAIN-CONTAINING ADAPTER PROTEIN F; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H0YKA8,
KW ECO:0007829|PeptideAtlas:H0YKA8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 160..199
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000452726.1"
SQ SEQUENCE 199 AA; 22094 MW; 83B1CA11A797F1D6 CRC64;
XGEGSAGASG APEKVPENDG YMEPYEAQKM MAEIRGSKET ATQPLPLYDT PYEPEEDGAT
AEGEGAPWPR ESRLPEDDER PPEEYDQPWE WKKERISKAF AAQFEGPEKS CLSPGREEKG
RLPPRLSAGN PKSAKPLSME PSSPLGEWTD PALPLENQVW YHGAISRTDA ENLLRLCKEA
SYLVRNSETS KNDFSLSLK
//
