ID H0YKF1_HUMAN Unreviewed; 133 AA.
AC H0YKF1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Proline-serine-threonine phosphatase interacting protein 1 {ECO:0000313|Ensembl:ENSP00000452779.1};
DE Flags: Fragment;
GN Name=PSTPIP1 {ECO:0000313|Ensembl:ENSP00000452779.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452779.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000452779.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000452779.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC090181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0YKF1; -.
DR PeptideAtlas; H0YKF1; -.
DR ProteomicsDB; 39639; -.
DR Antibodypedia; 2771; 200 antibodies from 26 providers.
DR Ensembl; ENST00000558870.1; ENSP00000452779.1; ENSG00000140368.14.
DR UCSC; uc059lyj.1; human.
DR HGNC; HGNC:9580; PSTPIP1.
DR VEuPathDB; HostDB:ENSG00000140368; -.
DR GeneTree; ENSGT00940000156932; -.
DR HOGENOM; CLU_1921839_0_0_1; -.
DR ChiTaRS; PSTPIP1; human.
DR Proteomes; UP000005640; Chromosome 15.
DR Bgee; ENSG00000140368; Expressed in granulocyte and 109 other cell types or tissues.
DR ExpressionAtlas; H0YKF1; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR CDD; cd11824; SH3_PSTPIP1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR030777; PSTPIP1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR PANTHER; PTHR15735:SF20; PROTEIN NERVOUS WRECK; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H0YKF1,
KW ECO:0007829|MaxQB:H0YKF1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 76..133
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000452779.1"
SQ SEQUENCE 133 AA; 14730 MW; 4A380B57383B38BF CRC64;
XDAGRLQHRR RHRQFHPGQE HGHRAPRFSG LLHGSPKTTS LAASAASTET LTPTPERNEG
VYTAIAVQEI QGNPASPAQE YRALYDYTAQ NPDELDLSAG DILEVILEGE DGWWTVERNG
QRGFVPGSYL EKL
//
