ID H0YLK8_HUMAN Unreviewed; 297 AA.
AC H0YLK8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Clusterin {ECO:0000313|Ensembl:ENSP00000453247.1};
DE Flags: Fragment;
GN Name=CLU {ECO:0000313|Ensembl:ENSP00000453247.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453247.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000453247.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000453247.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Microsome
CC {ECO:0000256|ARBA:ARBA00004144}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069}.
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DR EMBL; AF311103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0YLK8; -.
DR SMR; H0YLK8; -.
DR MassIVE; H0YLK8; -.
DR MaxQB; H0YLK8; -.
DR PeptideAtlas; H0YLK8; -.
DR PRIDE; H0YLK8; -.
DR ProteomicsDB; 39985; -.
DR Antibodypedia; 631; 1388 antibodies from 52 providers.
DR Ensembl; ENST00000560566.5; ENSP00000453247.1; ENSG00000120885.22.
DR UCSC; uc064llw.1; human.
DR HGNC; HGNC:2095; CLU.
DR NIAGADS; ENSG00000120885; -.
DR VEuPathDB; HostDB:ENSG00000120885; -.
DR GeneTree; ENSGT00530000063668; -.
DR ChiTaRS; CLU; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000120885; Expressed in lateral globus pallidus and 209 other cell types or tissues.
DR ExpressionAtlas; H0YLK8; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR033986; Clusterin_CS.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF1; CLUSTERIN; 1.
DR Pfam; PF01093; Clusterin; 1.
DR SMART; SM00030; CLb; 1.
DR PROSITE; PS00492; CLUSTERIN_1; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|EPD:H0YLK8,
KW ECO:0007829|MaxQB:H0YLK8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..297
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003546046"
FT DOMAIN 34..238
FT /note="Clusterin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00030"
FT COILED 64..105
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 297
FT /evidence="ECO:0000313|Ensembl:ENSP00000453247.1"
SQ SEQUENCE 297 AA; 34749 MW; 3E332849B9E4B82D CRC64;
MEACKDSRIG GMMKTLLLFV GLLLTWESGQ VLGDQTVSDN ELQEMSNQGS KYVNKEIQNA
VNGVKQIKTL IEKTNEERKT LLSNLEEAKK KKEDALNETR ESETKLKELP GVCNETMMAL
WEECKPCLKQ TCMKFYARVC RSGSGLVGRQ LEEFLNQSSP FYFWMNGDRI DSLLENDRQQ
THMLDVMQDH FSRASSIIDE LFQDRFFTRE PQDTYHYLPF SLPHRRPHFF FPKSRIVRSL
MPFSPYEPLN FHAMFQPFLE MIHEAQQAMD IHFHSPAFQH PPTEFIREGD DDRTVCR
//
