ID H0YN25_HUMAN Unreviewed; 195 AA.
AC H0YN25;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=ISL LIM homeobox 2 {ECO:0000313|Ensembl:ENSP00000453837.1};
GN Name=ISL2 {ECO:0000313|Ensembl:ENSP00000453837.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453837.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000453837.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000453837.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AC027243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0YN25; -.
DR SMR; H0YN25; -.
DR MassIVE; H0YN25; -.
DR PeptideAtlas; H0YN25; -.
DR ProteomicsDB; 40436; -.
DR Ensembl; ENST00000558656.1; ENSP00000453837.1; ENSG00000159556.10.
DR UCSC; uc059lwr.1; human.
DR HGNC; HGNC:18524; ISL2.
DR VEuPathDB; HostDB:ENSG00000159556; -.
DR GeneTree; ENSGT00940000153731; -.
DR HOGENOM; CLU_1539512_0_0_1; -.
DR Proteomes; UP000005640; Chromosome 15.
DR Bgee; ENSG00000159556; Expressed in primordial germ cell in gonad and 65 other cell types or tissues.
DR ExpressionAtlas; H0YN25; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048665; P:neuron fate specification; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd09366; LIM1_Isl; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR047169; ISL1/2-like.
DR InterPro; IPR047244; ISL1/2-like_LIM1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24204; INSULIN GENE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR24204:SF2; INSULIN GENE ENHANCER PROTEIN ISL-2; 1.
DR Pfam; PF00412; LIM; 1.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Proteomics identification {ECO:0007829|PeptideAtlas:H0YN25,
KW ECO:0007829|ProteomicsDB:H0YN25};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 25..87
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 94..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 195 AA; 21120 MW; 738BE232F542CC39 CRC64;
MVDIIFHYPF LGAMGDHSKK KPGTAMCVGC GSQIHDQFIL RVSPDLEWHA ACLKCAECSQ
YLDETCTCFV RDGKTYCKRD YVRRWVGPAA RVAPARAQAD GEDDPRADCA EREAAAHSAD
LLRRQPAARR SHEGAAGGDD RPEPAGHPRL VPEQALQGQE EIHSHEAAAA AAAQRQDEPS
GTDWDAPGGG QSHPP
//
