ID H0YNM2_HUMAN Unreviewed; 120 AA.
AC H0YNM2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Semaphorin 4B {ECO:0000313|Ensembl:ENSP00000454068.1};
DE Flags: Fragment;
GN Name=SEMA4B {ECO:0000313|Ensembl:ENSP00000454068.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000454068.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000454068.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000454068.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AC091167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H0YNM2; -.
DR MaxQB; H0YNM2; -.
DR PeptideAtlas; H0YNM2; -.
DR ProteomicsDB; 40604; -.
DR Antibodypedia; 2694; 280 antibodies from 26 providers.
DR Ensembl; ENST00000559247.1; ENSP00000454068.1; ENSG00000185033.15.
DR UCSC; uc059neb.1; human.
DR HGNC; HGNC:10730; SEMA4B.
DR VEuPathDB; HostDB:ENSG00000185033; -.
DR GeneTree; ENSGT00940000154870; -.
DR HOGENOM; CLU_2066708_0_0_1; -.
DR ChiTaRS; SEMA4B; human.
DR Proteomes; UP000005640; Chromosome 15.
DR Bgee; ENSG00000185033; Expressed in ileal mucosa and 145 other cell types or tissues.
DR ExpressionAtlas; H0YNM2; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF14; SEMAPHORIN-4B; 1.
DR Pfam; PF01437; PSI; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 1: Evidence at protein level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Proteomics identification {ECO:0007829|EPD:H0YNM2,
KW ECO:0007829|PeptideAtlas:H0YNM2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..41
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000454068.1"
SQ SEQUENCE 120 AA; 13066 MW; 3081C5A615D983BB CRC64;
XHIIEELQIF SSGQPVQNLL LDTHRGLLYA ASHSGVVQVP MANCSLYRSC GDCLLARDPY
CAWSGSSCKH VSLYQPQLAT RILSGPQAVD PGHRGSQRQG PLQRVFGCVP VFCTNRGEAM
//
