ID H0YTK9_TAEGU Unreviewed; 530 AA.
AC H0YTK9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Lymphocyte cytosolic protein 2 {ECO:0000313|Ensembl:ENSTGUP00000001622.2};
GN Name=LCP2 {ECO:0000313|Ensembl:ENSTGUP00000001622.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000001622.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000001622.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000001622.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0YTK9; -.
DR STRING; 59729.ENSTGUP00000001622; -.
DR Ensembl; ENSTGUT00000001636.2; ENSTGUP00000001622.2; ENSTGUG00000001570.2.
DR GeneTree; ENSGT00940000156835; -.
DR HOGENOM; CLU_040430_0_0_1; -.
DR InParanoid; H0YTK9; -.
DR OMA; GSRNQCM; -.
DR Proteomes; UP000007754; Chromosome 13.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0044853; C:plasma membrane raft; IEA:Ensembl.
DR GO; GO:0036398; C:TCR signalosome; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR CDD; cd09522; SAM_SLP76; 1.
DR CDD; cd09929; SH2_BLNK_SLP-76; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR14098:SF1; LYMPHOCYTE CYTOSOLIC PROTEIN 2; 1.
DR PANTHER; PTHR14098; SH2 DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 428..530
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 83..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..143
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..363
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 59553 MW; BAD95542C4FAEFE1 CRC64;
MDLRNVPYRS DVLTWDPEDL AEYFRTLKYK DCEKVVRKHS ISGQRFLNMS ENDIQKFPKL
RVPIVSKLSQ EINKNEGRLS FLPKWAQTQK SPENTGYTQD DGGWSSFDDD DDDDYESPDE
GQEKEDEADY ESPTEEPEEA EHDSDGYEPP PSNNEEAHHS VIFPAKSLPS STDYIDRPTT
TRSVHQLPHQ PPVPPQRPGL TPGPASFGGR SATLPAFPPP PSNNDLSRDR NMKPLKPPAP
SIDRSTKPSL DRLAPPYERE SPGSGKKPGI PEKPLVSQLR SLGEQLAMMP KPPVPPSDRY
ERGNPPPLRK QSPGKHSWPP HKKNEDEEDT ALQRPVPQLS LPPYSSNAFP PKSIKPPPKP
GSNSIPAAES SRNLSTTGSL PPRFRPGSNS RSPSRGPADM RPPLPIPSRQ TVYQANTEED
EGSLKDEWYV AFVSRPEAEA ALRKINKDGT FLVRDSSRKT VTHPYVLMVL YRDKVYNIQI
RYQEQDHLYL LGTSLKGKEE FSSVADIIDH FQRTPLLLID GKDRGSRNQS
//
