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Database: UniProt
Entry: H0YUA8_TAEGU
LinkDB: H0YUA8_TAEGU
Original site: H0YUA8_TAEGU 
ID   H0YUA8_TAEGU            Unreviewed;      2663 AA.
AC   H0YUA8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   08-NOV-2023, entry version 75.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSTGUP00000001876.2};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000001876.2, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000001876.2, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA   Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA   Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA   Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA   McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA   Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA   Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA   Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA   Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA   Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA   Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000001876.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC       that mediates the release of intracellular calcium.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|RuleBase:RU368044}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC       extremity. Its large N-terminal cytoplasmic region has the ligand-
CC       binding site in the N-terminus and modulatory sites in the middle
CC       portion immediately upstream of the channel region.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR   STRING; 59729.ENSTGUP00000001876; -.
DR   Ensembl; ENSTGUT00000001894.2; ENSTGUP00000001876.2; ENSTGUG00000001798.2.
DR   GeneTree; ENSGT00940000157078; -.
DR   HOGENOM; CLU_000206_1_0_1; -.
DR   InParanoid; H0YUA8; -.
DR   OMA; WLMWTDK; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000007754; Chromosome 26.
DR   GO; GO:0098554; C:cytoplasmic side of endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR   GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.80.10.50; -; 2.
DR   Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR45816:SF1; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3; 1.
DR   PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR   SUPFAM; SSF82109; MIR domain; 2.
DR   PROSITE; PS50919; MIR; 2.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU368044};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW   ECO:0000256|RuleBase:RU368044};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU368044};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU368044};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU368044};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW   ECO:0000256|RuleBase:RU368044};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU368044};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU368044};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT   TRANSMEM        2198..2223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2235..2253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2265..2285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2321..2346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2366..2388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2490..2513
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   DOMAIN          113..173
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          232..288
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   REGION          324..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1131..1159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1794..1833
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2644..2663
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1809..1824
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2663 AA;  304446 MW;  26F16C00F159B74A CRC64;
     MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KDKIADVVLL QKLQHAAQME QKQNETENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LADNAGCKEV NSVNCNTSWK INLFMQFCDH MEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LHVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEEN PSYKGDVAEP KAAPTGGSSR ASRRNTGEKI KYRLVAVPHG
     NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDIDEE RPIRLMLGTC
     PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASVVEKMN EGFLSQNDRR FVIQLLEDLV
     FFVSDVPNNG QNVLDIVVTK PNRERQKLMR EQNILKQIFG ILKAPFKDKG GEGPLVRLEE
     LSDQKNAPYQ YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDSK
     NSDILIKTEL RPVKEMSQTH EYLSIEYLEE EVWLTWTDKN NDHHEKSIRQ LAQEARAGNA
     HDENVLSYYR YQLKLFARMC LDRQYLAIKE ISQQLGVDLI FLCMADEMLP FDLRASFCHL
     MLHVHVDRDP QELVMPVKFA RLWTEIPTAI TIKDYDSNLN VSRDDKKNKF ASTMEFVEDY
     LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQNPQL
     MMQAVYNDEV TGKNVRRSIQ GVGQMMSTMV LSRKQSIFSP PSLSTGSAPE QVDRGRSIES
     ENIVVMETKL KILEILQFIL NVRLDYRISY LLSVFKKEFV EVYPMQDSAA DGTAPAFDST
     TAAMNLDRIG EHAEAMFGVG KSSSMLEVDD EGGRMFLRVL IHLTMHDYPP LISGSLQLLF
     KHFSQRQEVL HTFKQVQLLI SAQDVENYKV IKSELDKLRT MVEKSELWVD KKGSTKGDST
     GEGNKKEKKE HGADEEVIAP GEKSSENYQI VKGILERLNK MCGVGEQVRK KQQRLLKNMD
     AHKVMLDLLQ IPYEKGDAKM MEILKFTHQF LQKFCAGNQE NQALLHKHLN LFLTPGLLEA
     ETMQHIFLNN YQLCSEINET VPQHFIHCVA THGRHVQYLD FLHTIIKAEG KYVKKCQDMI
     MTELTNAGDD VVVFYNDKAS LATLLEMMTA ARDGVEENSP LMYHISLVDL LAACAEGKNV
     YTEIKCTSLL PLEDVVRVVT HEDCITEVKM AYVNFVNHCY VDTEVEMKEI YTSNHIWTLF
     ENFTLDMAQM CKKREKRLPD ATLEKYVLTV VLDTINAFFS SPFSENSTSL QTHQTIVVQL
     LQSTMRLLEC PWLQQQHKSS VESCIRTLAM VAKSRSIALP MDLDAHVSSL LNSSSTSTVQ
     RNTSSYKAAT RSFPRVSTTP NQWDYKNIIE KLQDIISALE DRLKPLVEAE LSVLVDVLHR
     PELLFMEGTE AFQRCESGGF LSKLVQHTKD LMETEEKLCI KVLRTLQQML VKRNKYGERG
     NLLRKMLMNN YLQNKRSSSK GEMGDAAGGG QDQDWSAIAA VQCRLDREGA TKLVADLIMN
     TKNEKIFQES ILLAIRLLDG GNTEIQKSFY NLMTSDKKSE KFFKVLHDRM KKAQQETKST
     VSVNMSDIGN KPREDKDEPE PGTKGRGDTF LMPGTPTRYP MAVGFRKGHD PGEQGQNNEM
     GVTVLIMEPI LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL VCETLQFLDI MCGSTTGGLG
     LLGLYINEYN VALITQTLET LTEYCQGPCH ENQSCIVTHE SNGIDIITAL ILNDISPLCK
     YRMDLVLQLK DNASKLLLAL MESRHDSENA ERILISLRPQ ELVDVIKKAY LQEEECENAE
     VSPREVGHNI YILALQLSRH NKSLQQLLKP VKRIQEEEEE GISSMLSLNN KQLSQMLKST
     APVQEEEEDP LAYYEKHTSQ IEIVRLDRSM EQIIFPVPGI CEFLTKETKY RLFTTTEQDE
     QGSKVSDFFD QSSFLHNEME WQKKLRSMPL MYWFSRRMTL WGSISFNLAV FINIIIAFFY
     PYVEATSMGV LDSPLISLLF WILICFSIMA LFTKRYGVRP LLVALILRSI YYLGIGLTLN
     ILGALNLTNK IVFVVSFVGN RGTFIRGYKA MIMDVEFLYH VGYIVTSVLG LFVHELFYSI
     LLFDLIYREE TLFNVIKSVT RNGRSILLTA LLALILVYLF SIVGFLFLKD DFILEVDRLP
     DSKAKDDPLG MQKNLETFME SCSSDKISCS AASTALEAEP EQWERACDTL LMCIVTVLNH
     GLRNGGGVGD ILRKPSKDES LFPARVVYDL LFFFIVIIIV LNLIFGVIID TFADLRSEKQ
     KKEEILKTTC FICGLERDKF DNKTVSFEEH IKYEHNMWNY LYFIVLVRVK NKTDYTGPES
     YVAQMIKNKN LDWFPRMRAM SLVSNEGEGE QNEIRNLQDK LNTTMKLVSH LTSQLNELKE
     QMTEQRKRRQ RMGFVDVQNT MNH
//
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