ID H0YUA8_TAEGU Unreviewed; 2663 AA.
AC H0YUA8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 08-NOV-2023, entry version 75.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=ITPR3 {ECO:0000313|Ensembl:ENSTGUP00000001876.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000001876.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000001876.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000001876.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR STRING; 59729.ENSTGUP00000001876; -.
DR Ensembl; ENSTGUT00000001894.2; ENSTGUP00000001876.2; ENSTGUG00000001798.2.
DR GeneTree; ENSGT00940000157078; -.
DR HOGENOM; CLU_000206_1_0_1; -.
DR InParanoid; H0YUA8; -.
DR OMA; WLMWTDK; -.
DR TreeFam; TF312815; -.
DR Proteomes; UP000007754; Chromosome 26.
DR GO; GO:0098554; C:cytoplasmic side of endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF1; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 4.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2198..2223
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2235..2253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2265..2285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2321..2346
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2366..2388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2490..2513
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 113..173
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 232..288
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 324..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1794..1833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2644..2663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1809..1824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2663 AA; 304446 MW; 26F16C00F159B74A CRC64;
MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
PMNRYSAQKQ YWKAKQTKQD KDKIADVVLL QKLQHAAQME QKQNETENKK VHGDVVKYGS
VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
DKVILNPVNA GQPLHASNYE LADNAGCKEV NSVNCNTSWK INLFMQFCDH MEEVLKGGDV
VRLFHAEQEK FLTCDEYKGK LHVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
NGLYRFKHLA TGNYLAAEEN PSYKGDVAEP KAAPTGGSSR ASRRNTGEKI KYRLVAVPHG
NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDIDEE RPIRLMLGTC
PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASVVEKMN EGFLSQNDRR FVIQLLEDLV
FFVSDVPNNG QNVLDIVVTK PNRERQKLMR EQNILKQIFG ILKAPFKDKG GEGPLVRLEE
LSDQKNAPYQ YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDSK
NSDILIKTEL RPVKEMSQTH EYLSIEYLEE EVWLTWTDKN NDHHEKSIRQ LAQEARAGNA
HDENVLSYYR YQLKLFARMC LDRQYLAIKE ISQQLGVDLI FLCMADEMLP FDLRASFCHL
MLHVHVDRDP QELVMPVKFA RLWTEIPTAI TIKDYDSNLN VSRDDKKNKF ASTMEFVEDY
LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQNPQL
MMQAVYNDEV TGKNVRRSIQ GVGQMMSTMV LSRKQSIFSP PSLSTGSAPE QVDRGRSIES
ENIVVMETKL KILEILQFIL NVRLDYRISY LLSVFKKEFV EVYPMQDSAA DGTAPAFDST
TAAMNLDRIG EHAEAMFGVG KSSSMLEVDD EGGRMFLRVL IHLTMHDYPP LISGSLQLLF
KHFSQRQEVL HTFKQVQLLI SAQDVENYKV IKSELDKLRT MVEKSELWVD KKGSTKGDST
GEGNKKEKKE HGADEEVIAP GEKSSENYQI VKGILERLNK MCGVGEQVRK KQQRLLKNMD
AHKVMLDLLQ IPYEKGDAKM MEILKFTHQF LQKFCAGNQE NQALLHKHLN LFLTPGLLEA
ETMQHIFLNN YQLCSEINET VPQHFIHCVA THGRHVQYLD FLHTIIKAEG KYVKKCQDMI
MTELTNAGDD VVVFYNDKAS LATLLEMMTA ARDGVEENSP LMYHISLVDL LAACAEGKNV
YTEIKCTSLL PLEDVVRVVT HEDCITEVKM AYVNFVNHCY VDTEVEMKEI YTSNHIWTLF
ENFTLDMAQM CKKREKRLPD ATLEKYVLTV VLDTINAFFS SPFSENSTSL QTHQTIVVQL
LQSTMRLLEC PWLQQQHKSS VESCIRTLAM VAKSRSIALP MDLDAHVSSL LNSSSTSTVQ
RNTSSYKAAT RSFPRVSTTP NQWDYKNIIE KLQDIISALE DRLKPLVEAE LSVLVDVLHR
PELLFMEGTE AFQRCESGGF LSKLVQHTKD LMETEEKLCI KVLRTLQQML VKRNKYGERG
NLLRKMLMNN YLQNKRSSSK GEMGDAAGGG QDQDWSAIAA VQCRLDREGA TKLVADLIMN
TKNEKIFQES ILLAIRLLDG GNTEIQKSFY NLMTSDKKSE KFFKVLHDRM KKAQQETKST
VSVNMSDIGN KPREDKDEPE PGTKGRGDTF LMPGTPTRYP MAVGFRKGHD PGEQGQNNEM
GVTVLIMEPI LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL VCETLQFLDI MCGSTTGGLG
LLGLYINEYN VALITQTLET LTEYCQGPCH ENQSCIVTHE SNGIDIITAL ILNDISPLCK
YRMDLVLQLK DNASKLLLAL MESRHDSENA ERILISLRPQ ELVDVIKKAY LQEEECENAE
VSPREVGHNI YILALQLSRH NKSLQQLLKP VKRIQEEEEE GISSMLSLNN KQLSQMLKST
APVQEEEEDP LAYYEKHTSQ IEIVRLDRSM EQIIFPVPGI CEFLTKETKY RLFTTTEQDE
QGSKVSDFFD QSSFLHNEME WQKKLRSMPL MYWFSRRMTL WGSISFNLAV FINIIIAFFY
PYVEATSMGV LDSPLISLLF WILICFSIMA LFTKRYGVRP LLVALILRSI YYLGIGLTLN
ILGALNLTNK IVFVVSFVGN RGTFIRGYKA MIMDVEFLYH VGYIVTSVLG LFVHELFYSI
LLFDLIYREE TLFNVIKSVT RNGRSILLTA LLALILVYLF SIVGFLFLKD DFILEVDRLP
DSKAKDDPLG MQKNLETFME SCSSDKISCS AASTALEAEP EQWERACDTL LMCIVTVLNH
GLRNGGGVGD ILRKPSKDES LFPARVVYDL LFFFIVIIIV LNLIFGVIID TFADLRSEKQ
KKEEILKTTC FICGLERDKF DNKTVSFEEH IKYEHNMWNY LYFIVLVRVK NKTDYTGPES
YVAQMIKNKN LDWFPRMRAM SLVSNEGEGE QNEIRNLQDK LNTTMKLVSH LTSQLNELKE
QMTEQRKRRQ RMGFVDVQNT MNH
//