ID H0YWG5_TAEGU Unreviewed; 1794 AA.
AC H0YWG5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Bromodomain and WD repeat domain containing 3 {ECO:0000313|Ensembl:ENSTGUP00000002638.2};
GN Name=BRWD3 {ECO:0000313|Ensembl:ENSTGUP00000002638.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000002638.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000002638.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000002638.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 59729.ENSTGUP00000029908; -.
DR Ensembl; ENSTGUT00000002666.2; ENSTGUP00000002638.2; ENSTGUG00000002561.2.
DR GeneTree; ENSGT00950000183107; -.
DR TreeFam; TF324197; -.
DR Proteomes; UP000007754; Chromosome 4A.
DR CDD; cd05529; Bromo_WDR9_I_like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16266:SF25; BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 178..219
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 220..261
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 262..298
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 360..393
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 463..505
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1164..1234
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1324..1407
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 665..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1436..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1555..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1569..1585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1586..1606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1607..1632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1647
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1794 AA; 202438 MW; CEA6E4031E98D6DF CRC64;
MAAAAAPTQL EAELYYLIAR FLQSGPCKKS AQVLVEELEE HQLIPRRLDW QGKEHRRSFE
DLVAVNAHIP PDYLLRICER LGPLLDKEIP QSVLGVQTLL GVGRQSLLRA AKDFRHTLWK
GSAFAALHRG RPPELPVNYG KPPNVVHILS ARQLTGCGRF SHLFPTSTYQ HMKMHKRILG
HLSSVYCIAF DRSGRRIFTG SDDCLVKIWA TDDGRLLSTL RGHSAEISDM AVNYENTLLA
AGSCDKVVRV WCLRTCAPLA VLQGHSASIT SIQFSPARKG TTRYLTSTGA DGTICFWQWH
ASTMKFKDRP VKFAERSRPG VQISCSSFSS GGMFIATGST DHVIRIYYLG SESPEKMAEL
ESHTDKVVAV QFCNNGDSLR FVSGSRDGTA RIWHYHQHDW KSLVLDMATK MTGNNVASGE
DKVTKLKVTM VAWDRYDATV ITAVNNFLLK VWNSSTGQLL HSLSGHDDEV FVLEAHPFDQ
RIVLSAGHDG NIFVWDIDKG TKIRNYFNMI EGQGHGAVFD CKFSPDGQHF ACTDSHGHLL
LFGFGCNKYY EKIPDQMFFH TDYRPLIRDA NNYVLDEQTQ QAPHLMPPPF LVDVDGNPHP
TRFQRLVPGR ENCKDEQLIP QLGYVANGDG EVVEQVIGQQ TNDQDESILD GMIRELQREQ
DLRLINEGET PPNPPLNRSH SVNGALRSPG LDVASPPNVG LRRSGQIEGV RQMHHNAPRS
QMATERDLMA WSRRVVVNEL PPGISKVQEE CRAAKGEIEI SLYTADKKRK PSHTLQRSEF
QAGGGRSLRR NQRKRQHAYQ TRSTIEHSQQ GASQNPCAHH DSDSSSEEDE TVGTSDASMD
DPVAAWQSES SSSDSSSEYS DWTADAGINL QPPKRQTRQA ARKICSSSED ENMKGTKGLE
PKRRKLKQPR KKVSNGLLSL EGEPSEEWLA PQWILDTIPR RSPFVPQMGD EIIYFRQGHE
AYVRAVRKAK IYSINMQKQP WNKMELREQE FVKTVGIKYE VGPPTLCCLK LAFLDPITGK
MTGESFSIKY HDMPDVIDFL VLHQFYNEAK ERNWQIGDRF RSIIDDAWWF GTVESQQPFQ
AEYPDSSFQC YSVHWDNNER ERMSPWDMEP IPEGTAYPEE VGAGVPVTPE ELTALLYKPQ
EGEWGAHSRD EECERVIRGI EQLLSLDISN PFAVPVDLSA YPMYCTVVAY PTDLTTIRRR
LENRFYRRIS ALMWEVRYIE HNARTFNEPD SPIVKAAKIV TDVLLRFIGD QSCTDILEIY
NKVKAEDLSS TDEEEEVAEV DVDSDAPGTS SGKRRVRRRV KRQPMKASAD AWKEQCQQLL
NLIYEREDSE PFRQPVDLFS YPVSAASTLR IVPPLDYRDI VDTPMDFSTV KETLEAGNYT
SPLEFYKDIR LIFCNSKAYT PNKKSRIYSM TLRLSALFEN HMKNIISEYK SALQCQKRKR
PRYRKRLRSS SSSPSTSRAS SPKGKQKQVK IQPKPNQNTS LPLTRTNSSV SSHGEEKPSL
SLTPQGQLRQ IPLFVSFLCA ILMGLFCVCL DHSPDGPLTN GDGREPRAGV KRKLLSASEE
DEHLEEAEEE EEEKKKRELK EKSGLSSSES GESGSSSSSE SRSGSDSDSE STSRTDQDYI
DGDHDYSKVV QSKKPKRKIK RKLTGGKRNW QGRGTGRRGR WGRWGRWSRG GRGGRGGRGC
GRGRGGGRGG RRGRGGRGAS RGATRAKRAR LADDEFENLF GGQFGENVFG GRFSRPPRIK
TRNEGRRTVL YNDDSDNDNF VHTEDPLNLG TSRSGRVRKM TEKARVSHLM GWNY
//
