ID H0YYT7_TAEGU Unreviewed; 774 AA.
AC H0YYT7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=TLE family member 4, transcriptional corepressor {ECO:0000313|Ensembl:ENSTGUP00000003468.2};
GN Name=TLE4 {ECO:0000313|Ensembl:ENSTGUP00000003468.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000003468.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000003468.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000003468.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR AlphaFoldDB; H0YYT7; -.
DR STRING; 59729.ENSTGUP00000003468; -.
DR Ensembl; ENSTGUT00000003504.2; ENSTGUP00000003468.2; ENSTGUG00000003264.2.
DR GeneTree; ENSGT01030000234519; -.
DR HOGENOM; CLU_007612_3_0_1; -.
DR InParanoid; H0YYT7; -.
DR OMA; RXSPSAS; -.
DR OrthoDB; 1333122at2759; -.
DR TreeFam; TF314167; -.
DR Proteomes; UP000007754; Chromosome Z.
DR GO; GO:1990907; C:beta-catenin-TCF complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 24..139
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 574..615
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 616..657
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 698..729
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 32..59
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 183..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 83855 MW; 49C255A1E7C1A192 CRC64;
MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV
TMAELNAIIG QQQLQAQHLS HGHGLPVPLT PHPSGLQPPA IPPIGSSAGL LALSSALGGQ
SHLPVKDEKK HHDNDHQRDR DSIKSSSVSP SASFRAAEKH RNSTDYSSDS KKQKTEEKEI
AARYDSDGEK SDDNLVVDVS NEDPSSPRGS PAHSPRENGL DKTRLLKKDA PISPASIASS
SSTPSSKSKE LSLNEKSTTP VSKSNTPTPR TDAPTPGSNS TPGLRPVPGK PPGVDPIASG
LRTPMAVPCP YPTPFGIVPH AGMNGELTSP GAAYAGLHNI SPQMSAAAAA AAAAAAYGRS
PVVGFDPHHH MRVPGIPPNL TGIPGGKPAY SFHVSADGQM QPVPFPPDAL IGPGIPRHAR
QINTLNHGEV VCAVTISNPT RHVYTGGKGC VKVWDISHPG NKSPVSQLDC LNRDNYIRSC
RLLPDGRTLI VGGEASTLSI WDLAAPTPRI KAELTSSAPA CYALAISPDS KVCFSCCSDG
NIAVWDLHNQ TLVRQFQGHT DGASCIDISN DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF
TSQIFSLGYC PTGEWLAVGM ENSNVEVLHV TKPDKYQLHL HESCVLSLKF AHCGKWFVST
GKDNLLNAWR TPYGASIFQS KESSSVLSCD ISVDDKYIVT GSGDKKATVY EVIY
//
