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Database: UniProt
Entry: H0YYU4_TAEGU
LinkDB: H0YYU4_TAEGU
Original site: H0YYU4_TAEGU 
ID   H0YYU4_TAEGU            Unreviewed;      1985 AA.
AC   H0YYU4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   28-MAR-2018, entry version 46.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A {ECO:0000313|Ensembl:ENSTGUP00000003476};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000003476, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000003476}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000003476}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; ABQF01058467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01058468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01058469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01058470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01058471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01058472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01058473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01058474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59729.ENSTGUP00000003476; -.
DR   Ensembl; ENSTGUT00000003512; ENSTGUP00000003476; ENSTGUG00000003307.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0YYU4; -.
DR   OMA; YMIDEDH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000007754; Chromosome LGE22.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    261    281       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    355    374       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    394    421       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    753    777       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    789    810       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    872    897       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    956    982       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1204   1222       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1243   1262       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1274   1299       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1319   1345       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1442   1468       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1526   1544       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1556   1574       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1586   1606       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1643   1671       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1746   1769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      143    428       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      505    705       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      759    986       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      996   1197       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1202   1476       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1525   1779       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1985 AA;  225942 MW;  D1294F8232CB9BA9 CRC64;
     MAARLLAPPG PESFKPFTPE SLANIEKHIA ELKKKQRSKQ DSSHRDDDED SKPKPNSDLE
     AGKNLPFIYG DIPKGLVAVP LEDFDPYYMT QKTFVVLNRG KTLFRFSATP ALYILSPFNL
     FRRIAIKILI HSYPFFITEF PRMIIMCTIL TNCVFMTFSN PPEWSKNVEY TFTGIYTFES
     LVKIIARGFC IDGFTFLRDP WNWLDFSVIM MAYVTEFVDL GNVSALRTFR VLRALKTISV
     IPGLKTIVGA LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCVI WPINVNETFL
     DNGSKGFDWE EYTNNMSNFY IIPGAPDPLL CGNSSDAGQC PEGYTCMKAG RNPNYGYTSF
     DTFSWAFLAL FRLMTQDFWE NLYQLTLRAA GKTYMIFFVL VIFVGSFYLV NLILAVVAMA
     YEEQNQATLE EAEQKEAEFK AMLEQLKKQQ EEAQAAAMVT SAGTVSEDAV EDDGGGRMSR
     SSSEISKLSS KSAKERRNRR KKRKDKELSE GDEKCDNEKV FKSESEDGMR RKAFRLPDNR
     LGRKFSIMNQ SLLSIPGSPF LSRHNSKSSI FSYKGRFRDP ASENEFADDE HSTVEESEGR
     RDSLFIPIRG RDRRSSYSGY SGYSQGSRSS RIFPTLRRSI KRNSTVDCNG VVSLIGGPPS
     SMPGGRILPE GTTEIEIRKK PGGSLLVSMD QVNASYGRKD RTNSVMTGLT NTLVEELEES
     QRKCPPCWYK FANTFLIWEC HPYWMKLKEI VNLIVMDPFV DLAITICIVL NTLFMAMEHH
     PMTPEFEHVL SVGNLVFTGI FTAEMFLKLI AMDPYYYFQE GWNIFDGFIV SLSLMELSLA
     DVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ
     LFGKSYKECV CKINPECELP RWHMHDFFHS FLIVFRVLCG EWIETMWDCM EVAGQAMCLI
     VFMMVMVIGN LVVLNLFLAL LLSSFSADNL AATDDDGEMN NLQISVIRIK KGIAWTKAKV
     REFMQAHFKQ READEVKPLD ELYDKKVNCI ANHTGADINR DVDFLKNGNG TTSGIGSSVE
     KYIIDEDHMS FINNPNLTVR VPIAVGESDF ENLNTEDFSS DTDPDGSKEK LDETSSSEGS
     TIDIKPEVEE VPVEAPEEYL DPDACFTEGC MQRCKCCQVN IEEGLGKSWW TLRKTCFLIV
     EHNWFETFII FMILLSSGAL AFEDIYIEQR KTIRTILEYA DKVFTYIFIL KMLLAWCAYG
     FVKFTNAWCW LDFLIVSVSL VSLIANALGY SELGAIKSLR TLRALRPLRA LSRFEGMRVV
     VNALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKYHYC FNETAEHRFE IEVVNNKTDC
     EALMPPNSTE IRWKNVKINF DNVGAGYLAL LQVATFKGWM DIMYAAVDSR KQEEQPKYED
     NIYMYIYFVI FIIFGSFFTL NLFIGVIIDN FNQQKKKISQ DIFMTEEQKK YYNAMKKLGS
     KKPQKPIPRP LNRIQGAVFD FVTQQAFDIV IMMLICLNMV TMMVETDTQS KQMEDILYWI
     NFVFVIFFTC ECVLKMFALR HYYFTIGWNI FDFVVVILSI VGMFLAEIIE KYFVSPTLFR
     VIRLARIGRI LRLIKGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIFSI FGMSNFAYVK
     HEAGIDDMFN FETFGNSMIC LFQITTSAGW DGLLLPILNR PPDCDLDKEH PGSGFKGDCG
     NPSVGIFFFV SYIIISFLIV VNMYIAIILE NFSVATEESA DPLSEDDFET FYEIWEKFDP
     DATQFIEYSK LADFADALEH PLRVPKPNTI ELIAMDLPMV SGDRIHCLDI LFAFTKRVLG
     DSGELDILRQ QMEERFVASN PSKVSYEPIT TTLRRKQEEV SAVVIQRAYR ARLARRGFVG
     RRAATATTKL ENGGATREKK EGTPSTASLP SYDSVTKPEK EKQQRAEEGR REKAKRQKDA
     RVAKC
//
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