ID H0YZQ4_TAEGU Unreviewed; 881 AA.
AC H0YZQ4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Beta-mannosidase {ECO:0000256|ARBA:ARBA00015707};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Lysosomal beta A mannosidase {ECO:0000256|ARBA:ARBA00032581};
DE AltName: Full=Mannanase {ECO:0000256|ARBA:ARBA00033445};
GN Name=MANBA {ECO:0000313|Ensembl:ENSTGUP00000003788.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000003788.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000003788.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000003788.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Exoglycosidase that cleaves the single beta-linked mannose
CC residue from the non-reducing end of all N-linked glycoprotein
CC oligosaccharides. {ECO:0000256|ARBA:ARBA00003150}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR AlphaFoldDB; H0YZQ4; -.
DR STRING; 59729.ENSTGUP00000003788; -.
DR Ensembl; ENSTGUT00000003830.2; ENSTGUP00000003788.2; ENSTGUG00000003629.2.
DR GeneTree; ENSGT00390000001670; -.
DR HOGENOM; CLU_005015_3_1_1; -.
DR InParanoid; H0YZQ4; -.
DR OMA; KRQWKGP; -.
DR OrthoDB; 2504097at2759; -.
DR TreeFam; TF105723; -.
DR Proteomes; UP000007754; Chromosome 4.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR041625; Beta-mannosidase_Ig.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF17753; Ig_mannosidase; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..881
FT /note="Beta-mannosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025630020"
FT DOMAIN 345..558
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
FT DOMAIN 704..797
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
FT DOMAIN 801..879
FT /note="Beta-mannosidase Ig-fold"
FT /evidence="ECO:0000259|Pfam:PF17753"
SQ SEQUENCE 881 AA; 100493 MW; 90561DE3C35F9746 CRC64;
MGLAALLLPA LLLPLAVAAG GPEVRSLRGS WRLRSGNGSV ALRAEVPGCV HTALLGRGLI
QDPYYRFNDV MYRWISLDNW TYSRMFKTPF DIRKWQKVNL VFEGVDTVAQ ILLNNVTLGR
TDNMFNRYSF DITSMIQEVN FVEVRFLSAV SYAAEQSRCY KAHSIPPACP PPVQKGECHV
NFIRKEQCSF SWDWGPSFPT QGIWKDVRIE AYNHYHLIYF SITPFFAKSA QQWYLEVESI
FDVVSSKPIA GLVTVNIPKL QTQQTFSVKL QPGEGSIVLL VNINKSAAVE AWWPNGHGKQ
TGYNMTTTFM MEAGCQMEKF SKVYFRTVEL VQEPIPGSPG LSFYFRINGR PIFIKGSNWI
PADSFQDRVT YDTLRLLLKS AADANMNALR VWGGGIYEQD EFYDICDEIG IMIWQDFMFA
CALYPTDQNY LESVRAEVSH QVRRLKSHPS IILWSGNNEN EAAIASNWFS IPYSDIGVYV
KDYVMLYVKN IRKIVLSEDK SRPFITSSPT NGLESVKEGW LSQNPYDTHY GDTHFYDYNS
DCWNWTVYPK TRFASEYGFQ SWPSFSTVEK VSSPEDWSYT SNFSLHRQHH EGGNIQMLQE
IGRHFKLPQS SDPVKQFKDM IYLTQVMQAQ CIKTETEFYR FSQSEIINGE GHTMGALYWQ
LNDIWQAPSW ASLEYGGKWK LLHYFAQNFF APLLPVAYED KGMLHIYGVS DLHEDHKLTL
RVVVHAWSSL EPVCTLAKEG VTVKAQSAVP IYKESISDLL ERCRNCTRRS CVITFCLVGG
DGLRSPTNHY FLSSLKDAVG LEKTQLRASV SQQDDIYVFV LQTTAIAPFV TLDVGSIKGR
FSDNGFLMTE KKKMVVFYPW EPTSAEELKS SLILTSLLDV V
//
